Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCNT1 | O60563 | 3/20 | 0.37 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.36 |
| ▸ | DYRK1A | Q13627 | 2/20 | 0.35 |
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.35 |
| ▸ | ADORA2B | P29275 | 1/20 | 0.35 |
| ▸ | MAPK14 | Q16539 | 2/20 | 0.34 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.34 |
| ▸ | MAPK12 | P53778 | 1/20 | 0.34 |
| ▸ | MAPK11 | Q15759 | 1/20 | 0.34 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.34 |
| ▸ | KHK | P50053 | 1/20 | 0.34 |
| ▸ | ATR | Q13535 | 2/20 | 0.33 |
| ▸ | PDCD1 | Q15116 | 2/20 | 0.33 |
| ▸ | CD274 | Q9NZQ7 | 2/20 | 0.33 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.33 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.33 |
| ▸ | MTOR | P42345 | 1/20 | 0.33 |
| ▸ | ATM | Q13315 | 1/20 | 0.33 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.33 |
| ▸ | ATRIP | Q8WXE1 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1225969 | 0.87 | MCHR1 (0.36) | CCNT1MCHR1DYRK1AIRAK4ADORA2B | |
| SCHEMBL1225735 | 0.87 | MCHR1 (0.36) | CCNT1MCHR1DYRK1AIRAK4ADORA2B | |
| SCHEMBL1462584 | 0.86 | TSHR (0.39) | MCHR1DYRK1AADORA2BMAPK1PIK3CD | |
| SCHEMBL18983775 | 0.77 | IKBKE (0.46) | — | |
| SCHEMBL30629342 | 0.71 | MCHR1 (0.39) | MCHR1IRAK4ADORA2BMAPK1PIK3CD | |
| SCHEMBL1462763 | 0.70 | CCNT1 (0.71) | CCNT1CDK9 | |
| SCHEMBL1226139 | 0.70 | CCNT1 (0.48) | CCNT1IRAK4PIK3CDPIK3CACSF1R | |
| SCHEMBL1462583 | 0.69 | MAP4K4 (0.39) | MCHR1IRAK4MAPK1PIK3CDPIK3CA | |
| SCHEMBL1564767 | 0.68 | MAPK1 (0.38) | MCHR1IRAK4MAPK1CSF1RFEN1 | |
| SCHEMBL1225532 | 0.67 | CCNT1 (0.52) | CCNT1IRAK4CDK9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2459535-A1 | PYRIDINE AND PYRAZINE DERIVATIVES AS PROTEIN KINASE MODULATORS | Novartis AG (CH) | 2012-06-06 | — | — | EP | disclosed |
| WO-2011012661-A1 | PYRIDINE AND PYRAZINE DERIVATIVES AS PROTEIN KINASE MODULATORS | NOVARTIS AG (CH) | 2011-02-03 | — | — | WO | disclosed |