Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAP4K4 | O95819 | 4/20 | 0.39 |
| ▸ | ASIC3 | Q9UHC3 | 1/20 | 0.38 |
| ▸ | IRAK4 | Q9NWZ3 | 2/20 | 0.38 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.37 |
| ▸ | PIK3CA | P42336 | 2/20 | 0.36 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.36 |
| ▸ | HTR6 | P50406 | 5/20 | 0.36 |
| ▸ | JAK2 | O60674 | 1/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.35 |
| ▸ | DHFR | P00374 | 1/20 | 0.35 |
| ▸ | DCPS | Q96C86 | 1/20 | 0.35 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.35 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.34 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.34 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2144739 | 0.77 | MCHR1 (0.43) | MCHR1DHFRDCPS | |
| SCHEMBL1224601 | 0.76 | MCHR1 (0.37) | MAP4K4ASIC3MCHR1PIK3CAPIK3CD | |
| SCHEMBL1225532 | 0.73 | CCNT1 (0.52) | MAP4K4IRAK4KCNH2HIF1A | |
| SCHEMBL31403748 | 0.71 | DHFR (0.40) | MCHR1PIK3CAPIK3CDHTR6DHFR | |
| SCHEMBL901899 | 0.70 | ASIC3 (0.57) | ASIC3IRAK4PDPK1KCNH2 | |
| SCHEMBL30629342 | 0.70 | MCHR1 (0.39) | MAP4K4IRAK4MCHR1PIK3CAPIK3CD | |
| SCHEMBL1224598 | 0.69 | CCNT1 (0.37) | IRAK4MCHR1PIK3CAPIK3CDMAPK1 | |
| SCHEMBL2143997 | 0.69 | MCHR1 (0.50) | MCHR1DHFRDCPS | |
| SCHEMBL20385485 | 0.68 | SMN1; SMN2 (0.43) | MAPK1HIF1A | |
| SCHEMBL901581 | 0.67 | MAP4K4 (0.52) | MAP4K4ASIC3MAPK1PDPK1DHFR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2473499-A1 | BIPYRIDINES USEFUL FOR THE TREATMENT OF PROLIFERATIVE DISEASES | Novartis AG (CH) | 2012-07-11 | — | — | EP | disclosed |
| WO-2011026911-A1 | BIPYRIDINES USEFUL FOR THE TREATMENT OF PROLIFERATIVE DISEASES | NOVARTIS AG (CH) | 2011-03-10 | — | — | WO | disclosed |