Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DAO | P14920 | 1/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.44 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.44 |
| ▸ | RAB9A | P51151 | 3/20 | 0.42 |
| ▸ | GAA | P10253 | 2/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.39 |
| ▸ | NOTUM | Q6P988 | 2/20 | 0.39 |
| ▸ | TSHR | P16473 | 2/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | PKM | P14618 | 2/20 | 0.37 |
| ▸ | NPC1 | O15118 | 1/20 | 0.37 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.37 |
| ▸ | TTK | P33981 | 1/20 | 0.36 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.36 |
| ▸ | INCENP | Q9NQS7 | 1/20 | 0.36 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.36 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.36 |
| ▸ | GSR | P00390 | 1/20 | 0.34 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13614197 | 0.79 | DAO (0.54) | DAOALDH1A1TDP1RAB9AGAA | |
| SCHEMBL261339 | 0.78 | GABRA1 (0.45) | ALDH1A1RAB9AGAASMN1; SMN2TSHR | |
| SCHEMBL1149578 | 0.77 | DAO (0.61) | DAOALDH1A1TDP1RAB9AGAA | |
| SCHEMBL6899153 | 0.76 | DAO (0.60) | DAOTDP1RAB9AGAASMN1; SMN2 | |
| SCHEMBL1149740 | 0.75 | LTB4R2 (0.52) | DAOALDH1A1RAB9AGAASMN1; SMN2 | |
| SCHEMBL875351 | 0.75 | DAO (0.54) | DAOALDH1A1TDP1RAB9AGAA | |
| SCHEMBL2919651 | 0.75 | DAO (0.54) | DAOALDH1A1TDP1RAB9AGAA | |
| Hydrochloric Acid SCHEMBL6941257 | 0.73 | DAO (0.53) | DAOALDH1A1TDP1RAB9AGAA | |
| SCHEMBL5710422 | 0.73 | DAO (0.53) | DAOALDH1A1TDP1RAB9AGAA | |
| SCHEMBL1869219 | 0.72 | ALDH1A1 (0.60) | ALDH1A1TDP1GAASMN1; SMN2TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2281822-B1 | New dihydroindolone derivatives, method of preparing same and pharmaceutical compositions containing them | SERVIER LAB (FR) | 2013-01-16 | — | — | EP | disclosed |
| EP-2281822-A1 | New dihydroindolone derivatives, method of preparing same and pharmaceutical compositions containing them | Les Laboratoires Servier (FR) | 2011-02-09 | — | — | EP | disclosed |