Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 9/20 | 0.55 |
| ▸ | POLB | P06746 | 1/20 | 0.55 |
| ▸ | NQO2 | P16083 | 1/20 | 0.54 |
| ▸ | NPC1 | O15118 | 2/20 | 0.53 |
| ▸ | MAPT | P10636 | 8/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 6/20 | 0.50 |
| ▸ | HTT | P42858 | 4/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.50 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.50 |
| ▸ | RAB9A | P51151 | 1/20 | 0.50 |
| ▸ | SLC2A1 | P11166 | 1/20 | 0.48 |
| ▸ | MEN1 | O00255 | 7/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.48 |
| ▸ | HPGD | P15428 | 1/20 | 0.47 |
| ▸ | LMNA | P02545 | 3/20 | 0.46 |
| ▸ | GAA | P10253 | 1/20 | 0.46 |
| ▸ | JAK2 | O60674 | 1/20 | 0.46 |
| ▸ | MITF | O75030 | 1/20 | 0.46 |
| ▸ | PAX8 | Q06710 | 1/20 | 0.46 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1225258 | 0.97 | KMT2A (0.57) | KMT2APOLBNQO2NPC1MAPT | |
| Bromide SCHEMBL6113767 | 0.96 | KMT2A (0.56) | KMT2APOLBNQO2NPC1MAPT | |
| SCHEMBL1226543 | 0.78 | NQO2 (0.59) | KMT2ANQO2NPC1MAPTSMN1; SMN2 | |
| SCHEMBL8559988 | 0.76 | NFE2L2 (0.47) | KMT2APOLBNQO2NPC1MAPT | |
| SCHEMBL5271563 | 0.76 | MAPT (0.59) | KMT2ANQO2NPC1MAPTSMN1; SMN2 | |
| SCHEMBL5276926 | 0.76 | MAPT (0.59) | KMT2ANQO2NPC1MAPTSMN1; SMN2 | |
| SCHEMBL1226503 | 0.76 | MAPT (0.63) | KMT2ANQO2NPC1MAPTSMN1; SMN2 | |
| SCHEMBL1225549 | 0.74 | KMT2A (0.62) | KMT2APOLBNPC1MAPTSMN1; SMN2 | |
| SCHEMBL7468007 | 0.72 | KMT2A (0.60) | KMT2APOLBNPC1MAPTSMN1; SMN2 | |
| SCHEMBL10940074 | 0.72 | CYP19A1 (0.62) | NPC1MAPTSMN1; SMN2HTTMAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2459737-B1 | NOVEL NITROREDUCTASE ENZYMATIC SUBSTRATES | BIOMERIEUX SA (FR) | 2014-10-29 | — | — | EP | claimed |
| US-8592175-B2 | Nitroreductase enzymatic substrates | bioMérieux, S.A. (FR) | 2013-11-26 | — | — | US | claimed |
| EP-2459737-A2 | NOVEL NITROREDUCTASE ENZYMATIC SUBSTRATES | Biomérieux (FR) | 2012-06-06 | — | — | EP | claimed |
| US-20120129204-A1 | NOVEL NITROREDUCTASE ENZYMATIC SUBSTRATES | bioMerieux, SA (FR) | 2012-05-24 | — | — | US | claimed |
| WO-2011012824-A2 | NOVEL NITROREDUCTASE ENZYMATIC SUBSTRATES | bioMérieux (FR) | 2011-02-03 | — | — | WO | claimed |
| EP-2459737-B1 | NOVEL NITROREDUCTASE ENZYMATIC SUBSTRATES | BIOMERIEUX SA (FR) | 2014-10-29 | — | — | EP | disclosed |
| US-8592175-B2 | Nitroreductase enzymatic substrates | bioMérieux, S.A. (FR) | 2013-11-26 | — | — | US | disclosed |
| EP-2459737-A2 | NOVEL NITROREDUCTASE ENZYMATIC SUBSTRATES | Biomérieux (FR) | 2012-06-06 | — | — | EP | disclosed |
| US-20120129204-A1 | NOVEL NITROREDUCTASE ENZYMATIC SUBSTRATES | bioMerieux, SA (FR) | 2012-05-24 | — | — | US | disclosed |
| WO-2011012824-A2 | NOVEL NITROREDUCTASE ENZYMATIC SUBSTRATES | bioMérieux (FR) | 2011-02-03 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120129204-A1 | NOVEL NITROREDUCTASE ENZYMATIC SUBSTRATES | CBR1, CBR3, POR | KMT2A 3575/4885POLB 2150/4885NQO2 158/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.