Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH2 | P25021 | 2/20 | 0.34 |
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9103338 | 0.89 | KDM4E (0.32) | KDM4E | |
| SCHEMBL512167 | 0.81 | HRH2 (0.32) | HRH2HRH3KDM4E | |
| SCHEMBL6472094 | 0.74 | HRH2 (0.35) | HRH2HRH3KDM4E | |
| SCHEMBL8636197 | 0.71 | NOS1 (0.38) | HRH2HRH3 | |
| SCHEMBL8634429 | 0.71 | NOS1 (0.38) | HRH2HRH3 | |
| SCHEMBL8634425 | 0.71 | NOS1 (0.38) | HRH2HRH3 | |
| SCHEMBL8636193 | 0.71 | NOS1 (0.38) | HRH2HRH3 | |
| SCHEMBL2738580 | 0.71 | LIMK1 (0.45) | — | |
| SCHEMBL4421661 | 0.71 | KDM4E (0.36) | KDM4E | |
| SCHEMBL30162228 | 0.68 | ACHE (0.57) | KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2459197-A1 | COMPOUNDS FOR THE REDUCTION OF -AMYLOID PRODUCTION | Bristol-Myers Squibb Company (US) | 2012-06-06 | — | — | EP | claimed |
| WO-2011014535-A1 | COMPOUNDS FOR THE REDUCTION OF β-AMYLOID PRODUCTION | BRISTOL-MYERS SQUIBB COMPANY (US) | 2011-02-03 | — | — | WO | claimed |
| CN-102548557-B | Compounds for reducing beta-amyloid production | BRISTOL MYERS SQUIBB CO | 2014-12-24 | — | — | CN | disclosed |
| EP-2459197-A1 | COMPOUNDS FOR THE REDUCTION OF -AMYLOID PRODUCTION | Bristol-Myers Squibb Company (US) | 2012-06-06 | — | — | EP | disclosed |
| WO-2011014535-A1 | COMPOUNDS FOR THE REDUCTION OF β-AMYLOID PRODUCTION | BRISTOL-MYERS SQUIBB COMPANY (US) | 2011-02-03 | — | — | WO | disclosed |