Predicted protein targets (top 2)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GGPS1 | O95749 | 16/20 | 0.69 |
| ▸ | FDPS | P14324 | 6/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12060626 | 0.92 | GGPS1 (0.77) | GGPS1FDPS | |
| SCHEMBL12060529 | 0.89 | GGPS1 (0.86) | GGPS1FDPS | |
| SCHEMBL12060539 | 0.89 | GGPS1 (0.86) | GGPS1FDPS | |
| SCHEMBL12257807 | 0.89 | GGPS1 (0.86) | GGPS1FDPS | |
| SCHEMBL12060612 | 0.88 | GGPS1 (0.61) | GGPS1FDPS | |
| SCHEMBL14199569 | 0.86 | GGPS1 (0.74) | GGPS1FDPS | |
| SCHEMBL12060526 | 0.86 | GGPS1 (0.59) | GGPS1FDPS | |
| SCHEMBL14199568 | 0.83 | GGPS1 (0.80) | GGPS1FDPS | |
| SCHEMBL14199586 | 0.83 | GGPS1 (0.80) | GGPS1FDPS | |
| SCHEMBL12257842 | 0.81 | GGPS1 (0.57) | GGPS1FDPS |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8012949-B2 | Pyridinium-1-yl, quinolinium-1-yl, and related compounds; parasitic infections, for example against trypanosomes; inhibiting the enzyme farnesyl diphosphate synthase | THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ILLINOIS (US) | 2011-09-06 | — | — | US | disclosed |
| US-20080255070-A1 | Bisphosphonate Compounds and Methods with Enhanced Potency for Multiple Targets including FPPS, GGPPS, AND DPPS | THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ILLINOIS (US) | 2008-10-16 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080255070-A1 | Bisphosphonate Compounds and Methods with Enhanced Potency for Multiple Targets including FPPS, GGPPS, AND DPPS | GGPS1, FDPS, FNTA | GGPS1 1/4885FDPS 2/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.