Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOX1 | Q9Y5S8 | 1/20 | 0.73 |
| ▸ | NPC1 | O15118 | 17/20 | 0.70 |
| ▸ | RAB9A | P51151 | 17/20 | 0.70 |
| ▸ | GAA | P10253 | 12/20 | 0.70 |
| ▸ | SMN1; SMN2 | Q16637 | 11/20 | 0.70 |
| ▸ | MAPT | P10636 | 10/20 | 0.70 |
| ▸ | KMT2A | Q03164 | 9/20 | 0.70 |
| ▸ | MEN1 | O00255 | 8/20 | 0.70 |
| ▸ | NFKB1 | P19838 | 6/20 | 0.70 |
| ▸ | NFKB2 | Q00653 | 6/20 | 0.70 |
| ▸ | RELA | Q04206 | 6/20 | 0.70 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.70 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.70 |
| ▸ | POLB | P06746 | 5/20 | 0.70 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.70 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.70 |
| ▸ | MCL1 | Q07820 | 2/20 | 0.70 |
| ▸ | KLF5 | Q13887 | 1/20 | 0.70 |
| ▸ | NSD2 | O96028 | 1/20 | 0.70 |
| ▸ | RECQL | P46063 | 1/20 | 0.70 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12258440 | 0.83 | NPC1 (0.76) | NPC1RAB9AGAASMN1; SMN2MAPT | |
| SCHEMBL13187328 | 0.83 | RAB9A (0.76) | NPC1RAB9AGAASMN1; SMN2MAPT | |
| SCHEMBL12581545 | 0.82 | NPC1 (0.75) | NPC1RAB9AGAASMN1; SMN2MAPT | |
| SCHEMBL26935144 | 0.82 | MAPT (0.72) | NPC1RAB9AGAASMN1; SMN2MAPT | |
| SCHEMBL12258152 | 0.82 | NPC1 (1.00) | NPC1RAB9AGAASMN1; SMN2MAPT | |
| SCHEMBL29859752 | 0.82 | MAPT (0.72) | NPC1RAB9AGAASMN1; SMN2MAPT | |
| SCHEMBL26915293 | 0.82 | MAPT (0.72) | NPC1RAB9AGAASMN1; SMN2MAPT | |
| SCHEMBL12258442 | 0.81 | NPC1 (0.76) | NOX1NPC1RAB9AGAASMN1; SMN2 | |
| SCHEMBL13187334 | 0.81 | NPC1 (0.72) | NPC1RAB9AGAASMN1; SMN2MAPT | |
| SCHEMBL13187300 | 0.80 | NPC1 (0.70) | NPC1RAB9AGAASMN1; SMN2MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20110263540-A1 | SMALL-MOLECULE INHIBITORS OF PROTEIN SYNTHESIS INACTIVATING TOXINS | MAYO FOUNDATION FOR MEDICAL EDUCATION AND RESEARCH | 2011-10-27 | — | — | US | disclosed |
| WO-2010053606-A9 | SMALL-MOLECULE INHIBITORS OF PROTEIN SYNTHESIS INACTIVATING TOXINS | MAYO FOUNDATION FOR MEDICAL EDUCATION AND RESEARCH (US) | 2010-09-02 | — | — | WO | disclosed |
| WO-2010053606-A2 | SMALL-MOLECULE INHIBITORS OF PROTEIN SYNTHESIS INACTIVATING TOXINS | MAYO FOUNDATION FOR MEDICAL EDUCATION AND RESEARCH (US) | 2010-05-14 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110263540-A1 | SMALL-MOLECULE INHIBITORS OF PROTEIN SYNTHESIS INACTIVATING TOXINS | MRPS27, MRPS22, MRPS23 | NOX1 3905/4885NPC1 4228/4885RAB9A 2347/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.