⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10388071 | 0.81 | — | — | |
| SCHEMBL20843942 | 0.78 | TSHR (0.41) | — | |
| SCHEMBL22833121 | 0.77 | — | — | |
| SCHEMBL24743434 | 0.75 | — | — | |
| SCHEMBL10239251 | 0.74 | — | — | |
| SCHEMBL4546377 | 0.72 | GABRA1 (0.33) | — | |
| SCHEMBL13626136 | 0.71 | ALDH1A1 (0.33) | — | |
| SCHEMBL22432023 | 0.70 | — | — | |
| SCHEMBL15979645 | 0.70 | — | — | |
| SCHEMBL24380982 | 0.70 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20170246157-A1 | PIPERIDIN-4-YL AZETIDINE DERIVATIVES AS JAK1 INHIBITORS | INCYTE CORPORATION | 2017-08-31 | — | — | US | disclosed |
| US-9464088-B2 | Piperidin-4-yl azetidine derivatives as JAK1 inhibitors | INCYTE HOLDINGS CORPORATION (US) | 2016-10-11 | — | — | US | disclosed |
| US-20160255836-A1 | N-CYCLOALKYL-N-(BIHETEROCYCLYMETHYLENE)-(THIO)CARBOXAMIDE DERIVATIVES | BAYER CROPSCIENCE AKTIENGESELLSCHAFT (DE) | 2016-09-08 | — | — | US | disclosed |
| US-20160244433-A1 | N-HETARYL(THIO)CARBONYL-2-(BENZOCYCLOALKEN-1-YL)CYCLAMINES AND THEIR USE AS FUNGICIDES | BAYER CROPSCIENCE AKTIENGESELLSCHAFT (DE) | 2016-08-25 | — | — | US | disclosed |
| WO-2015055706-A2 | N-CYCLOALKYL-N-(BIHETEROCYCLYMETHYLENE)-(THIO)CARBOXAMIDE DERIVATIVES | BAYER CROPSCIENCE AG (DE) | 2015-04-23 | — | — | WO | disclosed |
| US-20140275031-A1 | PIPERIDIN-4-YL AZETIDINE DERIVATIVES AS JAK1 INHIBITORS | INCYTE CORPORATION (US) | 2014-09-18 | — | — | US | disclosed |
| US-8765734-B2 | Piperidin-4-yl azetidine derivatives as JAK1 inhibitors | INCYTE CORPORATION (US) | 2014-07-01 | — | — | US | disclosed |
| US-20110224190-A1 | PIPERIDIN-4-YL AZETIDINE DERIVATIVES AS JAK1 INHIBITORS | INCYTE CORPORATION | 2011-09-15 | — | — | US | disclosed |