SCHEMBL12263262

SCHEMBL12263262

Cc1c(C(=O)O)n[nH]c1N

nearest known ligand 0.55

Predicted protein targets (top 4)

geneUniProtsupporting neighboursconfidence
HCAR2 Q8TDS4 17/20 0.55
KMT2A Q03164 1/20 0.37
DAO P14920 1/20 0.36
TSHR P16473 1/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL4631308 0.77 HCAR2 (0.63) HCAR2DAO
SCHEMBL7234538 0.76 HCAR2 (0.57) HCAR2KMT2ADAOTSHR
SCHEMBL17065994 0.74 HCAR2 (0.55) HCAR2KMT2ADAOTSHR
SCHEMBL15859525 0.74 HCAR2 (0.55) HCAR2KMT2ADAOTSHR
SCHEMBL29954524 0.74 HCAR2 (0.59) HCAR2DAO
SCHEMBL31741716 0.74 HCAR2 (0.59) HCAR2KMT2ADAOTSHR
SCHEMBL2543083 0.74 HCAR2 (0.59) HCAR2KMT2ATSHR
SCHEMBL11094727 0.74 ALDH1A1 (0.41) KMT2ATSHR
SCHEMBL4877467 0.72 HCAR2 (0.53) HCAR2KMT2ADAOTSHR
SCHEMBL29956356 0.72 HCAR2 (0.53) HCAR2KMT2ADAOTSHR

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-103068842-B Insulin receptor INSR is had highly active single-chain insulin agonist 印第安纳大学研究及科技有限公司 2016-10-19 CN disclosed
CN-103068842-A Single chain insulin agonists exhibiting high activity at the insulin receptor UNIV INDIANA RES & TECH CORP 2013-04-24 CN disclosed
US-20110262397-A1 COMPOUNDS, COMPOSITIONS, AND METHODS FOR CONTROL OF HEPATITIS C VIRAL INFECTIONS APATH, LLC (US) 2011-10-27 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20110262397-A1 COMPOUNDS, COMPOSITIONS, AND METHODS FOR CONTROL OF HEPATITIS C VIRAL INFECTIONS HAVCR2, FABP1, HCCS HCAR2 2570/4885KMT2A 4066/4885DAO 625/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.