Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | APP | P05067 | 1/20 | 0.42 |
| ▸ | FBP1 | P09467 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 3/20 | 0.40 |
| ▸ | CYP19A1 | P11511 | 2/20 | 0.40 |
| ▸ | BCHE | P06276 | 1/20 | 0.40 |
| ▸ | MAOB | P27338 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 7/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.40 |
| ▸ | GAA | P10253 | 2/20 | 0.40 |
| ▸ | MEN1 | O00255 | 2/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
| ▸ | NPC1 | O15118 | 2/20 | 0.39 |
| ▸ | POLB | P06746 | 2/20 | 0.39 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 3/20 | 0.38 |
| ▸ | TP53 | P04637 | 1/20 | 0.38 |
| ▸ | PTGS2 | P35354 | 4/20 | 0.38 |
| ▸ | PTGS1 | P23219 | 2/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1226876 | 1.00 | APP (0.42) | APPFBP1RAB9ACYP19A1BCHE | |
| SCHEMBL1226875 | 1.00 | APP (0.42) | APPFBP1RAB9ACYP19A1BCHE | |
| Bromide SCHEMBL1227486 | 0.99 | APP (0.41) | APPFBP1RAB9ACYP19A1BCHE | |
| SCHEMBL12160328 | 0.83 | ERN1 (0.44) | RAB9AMAPTALDH1A1GAAMEN1 | |
| SCHEMBL13698927 | 0.81 | APP (0.34) | APPRAB9AMAOBMAPTMEN1 | |
| SCHEMBL29012247 | 0.81 | APP (0.34) | APPRAB9AMAOBMAPTMEN1 | |
| SCHEMBL29653731 | 0.81 | APP (0.34) | APPRAB9AMAOBMAPTMEN1 | |
| SCHEMBL14434778 | 0.79 | APP (0.39) | APPMAPTALDH1A1MEN1KMT2A | |
| SCHEMBL13138317 | 0.79 | RELA (0.45) | APPRAB9AMAPTALDH1A1MEN1 | |
| SCHEMBL9812776 | 0.79 | RELA (0.45) | APPRAB9AMAPTALDH1A1MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8883437-B2 | Nitroreductase enzymatic substrates | bioMérieux S.A. | 2014-11-11 | — | — | US | disclosed |
| EP-2459738-B1 | NOVEL NITROREDUCTASE ENZYMATIC SUBSTRATES | BIOMERIEUX SA (FR) | 2014-10-29 | — | — | EP | disclosed |
| EP-2459738-A2 | NOVEL NITROREDUCTASE ENZYMATIC SUBSTRATES | Biomérieux (FR) | 2012-06-06 | — | — | EP | disclosed |
| US-20120122137-A1 | Novel Nitroreductase Enzymatic Substrates | bioMérieux S.A. (FR) | 2012-05-17 | — | — | US | disclosed |
| WO-2011012826-A2 | NOVEL NITROREDUCTASE ENZYMATIC SUBSTRATES | bioMérieux (FR) | 2011-02-03 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120122137-A1 | Novel Nitroreductase Enzymatic Substrates | CBR3, CBR1, POR | APP 4223/4885FBP1 767/4885RAB9A 4541/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.