Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CSNK2A2 | P19784 | 8/20 | 0.67 |
| ▸ | CSNK2A1 | P68400 | 8/20 | 0.67 |
| ▸ | CSNK1D | P48730 | 1/20 | 0.42 |
| ▸ | RIPK1 | Q13546 | 6/20 | 0.39 |
| ▸ | STK17B | O94768 | 1/20 | 0.38 |
| ▸ | STK17A | Q9UEE5 | 1/20 | 0.38 |
| ▸ | CCNC | P24863 | 1/20 | 0.38 |
| ▸ | CDK8 | P49336 | 1/20 | 0.38 |
| ▸ | MAOA | P21397 | 1/20 | 0.37 |
| ▸ | MAOB | P27338 | 1/20 | 0.37 |
| ▸ | CA12 | O43570 | 1/20 | 0.37 |
| ▸ | CA1 | P00915 | 1/20 | 0.37 |
| ▸ | CA2 | P00918 | 1/20 | 0.37 |
| ▸ | CA9 | Q16790 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14634800 | 0.88 | CSNK2A2 (0.67) | CSNK2A2CSNK2A1CSNK1DRIPK1STK17B | |
| SCHEMBL12283706 | 0.83 | CSNK2A2 (0.95) | CSNK2A2CSNK2A1 | |
| SCHEMBL12283438 | 0.70 | NTRK1 (0.38) | CSNK2A2CSNK2A1 | |
| SCHEMBL12284245 | 0.68 | CSNK2A2 (0.68) | CSNK2A2CSNK2A1 | |
| SCHEMBL14635504 | 0.68 | CSNK2A2 (1.00) | CSNK2A2CSNK2A1 | |
| SCHEMBL22767691 | 0.67 | TDP1 (0.56) | STK17BSTK17AMAOAMAOBCA12 | |
| SCHEMBL31245898 | 0.67 | TDP1 (0.49) | CSNK2A2CSNK2A1STK17BSTK17ACCNC | |
| SCHEMBL31246004 | 0.67 | TDP1 (0.49) | CSNK2A2CSNK2A1STK17BSTK17ACCNC | |
| SCHEMBL22123680 | 0.66 | CSNK2A2 (0.44) | CSNK2A2CSNK2A1CSNK1DCCNCCDK8 | |
| SCHEMBL21366005 | 0.66 | CSNK1D (0.48) | CSNK2A2CSNK2A1CSNK1DSTK17BSTK17A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011123493-A1 | SUBSTITUTED PYRROLOTRIAZINES AS PROTEIN KINASE INHIBITORS | BRISTOL-MYERS SQUIBB COMPANY (US) | 2011-10-06 | — | — | WO | disclosed |