Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 3/20 | 0.36 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.36 |
| ▸ | GRIA1 | P42261 | 3/20 | 0.35 |
| ▸ | CACNG8 | Q8WXS5 | 3/20 | 0.35 |
| ▸ | MEN1 | O00255 | 2/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.34 |
| ▸ | PDE3B | Q13370 | 2/20 | 0.34 |
| ▸ | PDE3A | Q14432 | 2/20 | 0.34 |
| ▸ | CDC25A | P30304 | 1/20 | 0.33 |
| ▸ | CDC25B | P30305 | 1/20 | 0.33 |
| ▸ | CDC25C | P30307 | 1/20 | 0.33 |
| ▸ | DUSP3 | P51452 | 1/20 | 0.33 |
| ▸ | NPC1 | O15118 | 1/20 | 0.32 |
| ▸ | RAB9A | P51151 | 1/20 | 0.32 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.32 |
| ▸ | PSEN1 | P49768 | 1/20 | 0.32 |
| ▸ | PSEN2 | P49810 | 1/20 | 0.32 |
| ▸ | APH1B | Q8WW43 | 1/20 | 0.32 |
| ▸ | NCSTN | Q92542 | 1/20 | 0.32 |
| ▸ | APH1A | Q96BI3 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14991117 | 0.90 | GRIA1 (0.38) | MAPTGRIA1MEN1KMT2APDE3B | |
| SCHEMBL12289961 | 0.78 | PDE3B (0.41) | MAPTGRIA1CACNG8PDE3BPDE3A | |
| SCHEMBL12288210 | 0.76 | KCNH2 (0.49) | MAPTGRIA1CACNG8PDE3BPDE3A | |
| SCHEMBL12289966 | 0.75 | HSD11B1 (0.41) | P2RX7IL1B | |
| SCHEMBL12286536 | 0.72 | JAK2 (0.39) | MEN1KMT2ANPC1RAB9AMAPK1 | |
| SCHEMBL12289963 | 0.71 | JAK2 (0.46) | MAPK1PRKAA1PIM1 | |
| SCHEMBL22191096 | 0.70 | PSEN1 (0.52) | MAPTGRIA1MEN1KMT2APDE3B | |
| SCHEMBL12289929 | 0.70 | KCNA5 (0.39) | MAPTGRIA1CACNG8PDE3BPDE3A | |
| SCHEMBL2562421 | 0.69 | PSEN1 (0.40) | MAPTGRIA1MEN1KMT2APDE3B | |
| SCHEMBL12288220 | 0.69 | JAK2 (0.38) | MEN1KMT2ANPC1RAB9AMAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011133882-A1 | CERTAIN AMINO-PYRIDAZINES, COMPOSITIONS THEREOF, AND METHODS OF THEIR USE | CYTOKINETICS, INC. (US) | 2011-10-27 | — | — | WO | disclosed |