Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD11B1 | P28845 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | PDE5A | O76074 | 1/20 | 0.34 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.33 |
| ▸ | P2RX7 | Q99572 | 2/20 | 0.32 |
| ▸ | IL1B | P01584 | 1/20 | 0.31 |
| ▸ | ALOX5AP | P20292 | 3/20 | 0.31 |
| ▸ | PORCN | Q9H237 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14990461 | 0.90 | HSD11B1 (0.37) | HSD11B1KDM4EPDE5AKCNH2 | |
| SCHEMBL12287803 | 0.75 | MAPT (0.36) | P2RX7IL1B | |
| SCHEMBL12286602 | 0.71 | SLC6A3 (0.41) | KDM4EKCNH2P2RX7IL1BALOX5AP | |
| SCHEMBL12288211 | 0.67 | KCNH2 (0.51) | KDM4EKCNH2IL1B | |
| SCHEMBL12286734 | 0.67 | FGFR1 (0.36) | — | |
| SCHEMBL12287618 | 0.67 | ROCK2 (0.44) | ALOX5AP | |
| SCHEMBL12863970 | 0.67 | LYN (0.44) | HSD11B1KDM4E | |
| SCHEMBL12286520 | 0.66 | PSEN1 (0.36) | IL1B | |
| SCHEMBL12288257 | 0.66 | KCNH2 (0.43) | HSD11B1KCNH2 | |
| SCHEMBL12290007 | 0.65 | KCNH2 (0.53) | KDM4EKCNH2IL1BALOX5APPORCN |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011133882-A1 | CERTAIN AMINO-PYRIDAZINES, COMPOSITIONS THEREOF, AND METHODS OF THEIR USE | CYTOKINETICS, INC. (US) | 2011-10-27 | — | — | WO | disclosed |