Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RXFP1 | Q9HBX9 | 5/20 | 0.70 |
| ▸ | MEN1 | O00255 | 3/20 | 0.68 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.68 |
| ▸ | MAPT | P10636 | 7/20 | 0.60 |
| ▸ | TP53 | P04637 | 5/20 | 0.60 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.55 |
| ▸ | THRB | P10828 | 3/20 | 0.54 |
| ▸ | POLB | P06746 | 3/20 | 0.53 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.51 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14707904 | 0.92 | MAPT (0.60) | RXFP1MEN1KMT2AMAPTTP53 | |
| SCHEMBL12285666 | 0.86 | RXFP1 (0.73) | RXFP1MEN1KMT2AMAPTTP53 | |
| SCHEMBL12285491 | 0.83 | RXFP1 (1.00) | RXFP1MAPTTP53TDP1THRB | |
| SCHEMBL12288668 | 0.80 | RXFP1 (0.82) | RXFP1MAPTTP53TDP1THRB | |
| SCHEMBL470775 | 0.78 | MAPT (0.85) | RXFP1MEN1KMT2AMAPTTP53 | |
| SCHEMBL14707901 | 0.77 | MAPT (0.81) | RXFP1MEN1KMT2AMAPTTP53 | |
| SCHEMBL12286344 | 0.73 | RXFP1 (0.84) | RXFP1MEN1KMT2AMAPTTP53 | |
| SCHEMBL12286109 | 0.72 | RXFP1 (0.77) | RXFP1MAPTTP53TDP1POLB | |
| SCHEMBL14707905 | 0.72 | RXFP1 (0.71) | RXFP1MEN1KMT2AMAPTTP53 | |
| SCHEMBL12287169 | 0.71 | RXFP1 (0.80) | RXFP1MAPTTP53TDP1POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8927561-B2 | Pyrimidinedione anti-viral compounds | Kineta, Inc. (US) | 2015-01-06 | — | — | US | disclosed |
| WO-2011133722-A2 | ANTI-VIRAL COMPOUNDS | Kineta, Inc. (US) | 2011-10-27 | — | — | WO | disclosed |