Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RXFP1 | Q9HBX9 | 2/20 | 0.73 |
| ▸ | MAPT | P10636 | 10/20 | 0.70 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.70 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.70 |
| ▸ | MEN1 | O00255 | 2/20 | 0.70 |
| ▸ | THRB | P10828 | 2/20 | 0.69 |
| ▸ | TP53 | P04637 | 2/20 | 0.68 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.66 |
| ▸ | TSHR | P16473 | 1/20 | 0.64 |
| ▸ | GLA | P06280 | 1/20 | 0.63 |
| ▸ | LMNA | P02545 | 1/20 | 0.61 |
| ▸ | POLB | P06746 | 1/20 | 0.60 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14707901 | 0.91 | MAPT (0.81) | RXFP1MAPTKMT2ASMN1; SMN2MEN1 | |
| SCHEMBL470775 | 0.87 | MAPT (0.85) | RXFP1MAPTKMT2AMEN1THRB | |
| SCHEMBL12288667 | 0.86 | RXFP1 (0.70) | RXFP1MAPTKMT2ASMN1; SMN2MEN1 | |
| SCHEMBL12285491 | 0.85 | RXFP1 (1.00) | RXFP1MAPTSMN1; SMN2THRBTP53 | |
| SCHEMBL15854601 | 0.79 | POLB (0.74) | MAPTKMT2ASMN1; SMN2MEN1ALDH1A1 | |
| SCHEMBL14707898 | 0.79 | MAPT (0.85) | RXFP1MAPTKMT2ASMN1; SMN2MEN1 | |
| SCHEMBL12288668 | 0.79 | RXFP1 (0.82) | RXFP1MAPTTHRBTP53POLB | |
| SCHEMBL3309192 | 0.78 | S1PR2 (0.74) | MAPTKMT2ASMN1; SMN2TP53ALDH1A1 | |
| SCHEMBL12668678 | 0.78 | MAPT (0.57) | RXFP1MAPTKMT2ASMN1; SMN2MEN1 | |
| SCHEMBL1895578 | 0.78 | L3MBTL1 (0.75) | KMT2AMEN1THRBTP53ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8927561-B2 | Pyrimidinedione anti-viral compounds | Kineta, Inc. (US) | 2015-01-06 | — | — | US | disclosed |
| WO-2011133722-A2 | ANTI-VIRAL COMPOUNDS | Kineta, Inc. (US) | 2011-10-27 | — | — | WO | disclosed |