Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ROCK2 | O75116 | 11/20 | 0.49 |
| ▸ | ROCK1 | Q13464 | 9/20 | 0.49 |
| ▸ | JAK2 | O60674 | 3/20 | 0.49 |
| ▸ | KDR | P35968 | 3/20 | 0.49 |
| ▸ | PRKD3 | O94806 | 2/20 | 0.49 |
| ▸ | MAP4K4 | O95819 | 2/20 | 0.49 |
| ▸ | AKT2 | P31751 | 2/20 | 0.49 |
| ▸ | PIM3 | Q86V86 | 2/20 | 0.49 |
| ▸ | PBK | Q96KB5 | 2/20 | 0.49 |
| ▸ | GSK3B | P49841 | 2/20 | 0.49 |
| ▸ | PRKG1 | Q13976 | 2/20 | 0.49 |
| ▸ | CLK4 | Q9HAZ1 | 2/20 | 0.49 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.49 |
| ▸ | IRAK4 | Q9NWZ3 | 2/20 | 0.49 |
| ▸ | CHEK2 | O96017 | 2/20 | 0.49 |
| ▸ | PRKACA | P17612 | 2/20 | 0.49 |
| ▸ | RPS6KA3 | P51812 | 2/20 | 0.49 |
| ▸ | PRKCD | Q05655 | 2/20 | 0.49 |
| ▸ | PRKAA1 | Q13131 | 2/20 | 0.49 |
| ▸ | DYRK1A | Q13627 | 2/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1228819 | 0.84 | ROCK2 (0.45) | ROCK2ROCK1JAK2KDRPRKD3 | |
| SCHEMBL1229167 | 0.74 | ROCK2 (0.75) | ROCK2ROCK1JAK2KDRPRKD3 | |
| SCHEMBL1228817 | 0.69 | JAK2 (0.34) | ROCK2ROCK1JAK2KDRPRKD3 | |
| SCHEMBL4598150 | 0.68 | PRKD3 (0.45) | ROCK2ROCK1JAK2KDRPRKD3 | |
| SCHEMBL1229918 | 0.64 | ROCK1 (0.55) | ROCK2ROCK1JAK2KDRPRKD3 | |
| SCHEMBL1229136 | 0.63 | ROCK2 (0.71) | ROCK2ROCK1JAK2KDRPRKD3 | |
| SCHEMBL1230417 | 0.63 | ROCK2 (0.80) | ROCK2ROCK1JAK2KDRPRKD3 | |
| SCHEMBL1230054 | 0.62 | ROCK2 (0.51) | ROCK2ROCK1JAK2KDRPRKD3 | |
| SCHEMBL1230376 | 0.62 | ROCK1 (0.53) | ROCK2ROCK1JAK2KDRPRKD3 | |
| SCHEMBL5442402 | 0.62 | MAOB (0.74) | ROCK2ROCK1PRKD3MAP4K4GSK3B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2459184-A1 | MODULATION OF SGK1 EXPRESSION IN TH17 CELLS TO MODULATE TH17-MEDIATED IMMUNE RESPONSES | The Brigham and Women's Hospital, Inc. (US) | 2012-06-06 | — | — | EP | claimed |
| WO-2011014775-A1 | MODULATION OF SGK1 EXPRESSION IN TH17 CELLS TO MODULATE TH17-MEDIATED IMMUNE RESPONSES | THE BRIGHAM AND WOMEN'S HOSPITAL, INC. (US) | 2011-02-03 | — | — | WO | claimed |