Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A4 | P31645 | 10/20 | 0.42 |
| ▸ | SLC6A2 | P23975 | 5/20 | 0.42 |
| ▸ | SLC6A3 | Q01959 | 5/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | HTR2A | P28223 | 7/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | HTR1A | P08908 | 1/20 | 0.36 |
| ▸ | HTR1D | P28221 | 1/20 | 0.36 |
| ▸ | HTR1B | P28222 | 1/20 | 0.36 |
| ▸ | HTR2C | P28335 | 1/20 | 0.36 |
| ▸ | HTR1E | P28566 | 1/20 | 0.36 |
| ▸ | HTR7 | P34969 | 1/20 | 0.36 |
| ▸ | HTR2B | P41595 | 1/20 | 0.36 |
| ▸ | HTR5A | P47898 | 1/20 | 0.36 |
| ▸ | HTR6 | P50406 | 1/20 | 0.36 |
| ▸ | PNMT | P11086 | 1/20 | 0.34 |
| ▸ | KCNH2 | Q12809 | 6/20 | 0.33 |
| ▸ | NCF1 | P14598 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14872331 | 0.77 | SLC6A4 (0.44) | SLC6A4SLC6A2SLC6A3KDM4ECYP3A4 | |
| SCHEMBL12305665 | 0.76 | HSD17B10 (0.44) | SLC6A4SLC6A2SLC6A3KDM4ECYP3A4 | |
| SCHEMBL5591192 | 0.76 | CYP3A4 (0.44) | SLC6A4SLC6A2SLC6A3KDM4ECYP3A4 | |
| SCHEMBL12985880 | 0.75 | PNMT (0.38) | HTR2AHTR1AHTR2CHTR2BPNMT | |
| SCHEMBL807531 | 0.73 | CSNK2A1 (0.48) | SLC6A2SLC6A3CYP3A4PNMTLOXL2 | |
| SCHEMBL807271 | 0.73 | THRB (0.44) | KDM4EMAPTPNMT | |
| SCHEMBL17480806 | 0.73 | KDM4E (0.39) | KDM4ECYP3A4MAPTHTR7NCF1 | |
| SCHEMBL13339967 | 0.72 | KDM4E (0.52) | SLC6A4SLC6A2SLC6A3KDM4ECYP3A4 | |
| SCHEMBL13748018 | 0.72 | KDM4E (0.37) | KDM4EMAPTPNMT | |
| SCHEMBL4835197 | 0.72 | GAA (0.46) | SLC6A4SLC6A2SLC6A3KDM4EMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011113802-A2 | IMIDAZOPYRIDINE COMPOUNDS, COMPOSITIONS AND METHODS OF USE | F. HOFFMANN-LA ROCHE AG (CH) | 2011-09-22 | — | — | WO | disclosed |