SCHEMBL1229940

SCHEMBL1229940

Cc1ccccc1C=CC#N

nearest known ligand 0.46

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 5/20 0.46
TSHR P16473 4/20 0.46
KDM4E B2RXH2 7/20 0.43
RAB9A P51151 5/20 0.43
APOBEC3A P31941 1/20 0.43
APOBEC3G Q9HC16 1/20 0.43
MEN1 O00255 1/20 0.42
PABPC1 P11940 1/20 0.42
KMT2A Q03164 1/20 0.42
CYP1A2 P05177 2/20 0.40
TP53 P04637 1/20 0.40
CYP2D6 P10635 1/20 0.40
THPO P40225 1/20 0.40
HIF1A Q16665 1/20 0.40
NR1H2 P55055 1/20 0.40
NR1H3 Q13133 1/20 0.40
ACHE P22303 1/20 0.38
MAPT P10636 2/20 0.37
CA1 P00915 1/20 0.36
CA2 P00918 1/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL1229938 1.00 ALDH1A1 (0.46) ALDH1A1TSHRKDM4ERAB9AAPOBEC3A
Pyridine SCHEMBL11609450 0.88 RAB9A (0.40) ALDH1A1TSHRKDM4ERAB9AAPOBEC3A
SCHEMBL31571540 0.86 ALDH1A1 (0.42) ALDH1A1TSHRKDM4ERAB9AAPOBEC3A
SCHEMBL10396571 0.86 ALDH1A1 (0.42) ALDH1A1TSHRKDM4ERAB9AAPOBEC3A
SCHEMBL10383610 0.84 KDM4E (0.40) ALDH1A1TSHRKDM4EMEN1KMT2A
SCHEMBL11278545 0.83 KDM4E (0.36) ALDH1A1TSHRKDM4ERAB9AAPOBEC3A
SCHEMBL11278542 0.83 KDM4E (0.36) ALDH1A1TSHRKDM4ERAB9AAPOBEC3A
SCHEMBL24894400 0.79 ALDH1A1 (0.34) ALDH1A1TSHRKDM4ECYP1A2MAPT
SCHEMBL2121339 0.78 ALDH1A1 (0.52) ALDH1A1TSHRKDM4ERAB9AAPOBEC3A
SCHEMBL2121342 0.78 ALDH1A1 (0.52) ALDH1A1TSHRKDM4ERAB9AAPOBEC3A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 36 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-111606824-B Beta-amino nitrile compound and preparation method thereof 东北师范大学 2023-03-14 CN claimed
CN-111606824-A Beta-amino nitrile compound and preparation method thereof 东北师范大学 2020-09-01 CN claimed
CN-111606824-B Beta-amino nitrile compound and preparation method thereof 东北师范大学 2023-03-14 CN disclosed
EP-3553097-B1 COPOLYMER AND OPTICAL FILM USING SAME TOSOH CORP (JP) 2022-05-04 EP disclosed
US-11225540-B2 Copolymer and optical film using same TOSOH CORPORATION (JP) 2022-01-18 US disclosed
CN-110248971-B Copolymer and optical film using the same 东曹株式会社 2021-11-02 CN disclosed
CN-111606824-A Beta-amino nitrile compound and preparation method thereof 东北师范大学 2020-09-01 CN disclosed
US-20200095358-A1 COPOLYMER AND OPTICAL FILM USING SAME TOSOH CORPORATION (JP) 2020-03-26 US disclosed
EP-3553097-A1 COPOLYMER AND OPTICAL FILM USING SAME Tosoh Corporation (JP) 2019-10-16 EP disclosed
EP-2250595-B1 METHOD OF SELECTING AN OPTIMIZED DIVERSE POPULATION OF VARIANTS CODEXIS INC (US) 2017-06-14 EP disclosed
US-8504498-B2 Method of generating an optimized, diverse population of variants CODEXIS, INC. (US) 2013-08-06 US disclosed
US-6001884-A Calcium receptor-active molecules NPS PHARMACEUTICALS, INC. (US) 1999-12-14 US disclosed
US-5962314-A CERTAIN CELLS IN THE BODY RESPOND NOT ONLY TO CHEMICAL SIGNALS, BUT ALSO TO IONS SUCH AS EXTRACELLULAR CALCIUM IONS (CA.SUP.2+). THE INVENTION RELATES TO NUCLEIC ACIDS ENCODING SUCH RECEPTORS AND CELLS CONTAINING SUCH NUCLEIC ACIDS. NPS PHARMACEUTICALS, INC. (US) 1999-10-05 US disclosed
US-5858684-A CONTACTING RECOMBINANT CELL WITH TEST COMPOUND WHICH IS NOT VERAPAMIL OR GALLOPAMIL, DETERMINING ABILITY OF COMPOUND TO AFFECT ACTIVITIES OF INORGANIC ION RECEPTOR; DETERMINATION OF AGONIST AND ANTAGONIST DRUGS THE BRIGHAM AND WOMEN'S HOSPITAL, INC. (US) 1999-01-12 US disclosed
US-5763569-A POLYPEPTIDES AS CALCIUM RECEPTORS TO GENERATE ANTIBODIES THE BRIGHAM AND WOMEN'S HOSPITAL, INC (US) 1998-06-09 US disclosed
US-5688938-A Calcium receptor-active molecules THE BRIGHAM & WOMEN'S HOSPITAL, INC. (US) 1997-11-18 US disclosed
EP-0787122-A2 CALCIUM RECEPTOR-ACTIVE COMPOUNDS NPS PHARMACEUTICALS, INC. (US) 1997-08-06 EP disclosed
EP-0724561-A1 CALCIUM RECEPTOR-ACTIVE ARYLALKYL AMINES NPS PHARMACEUTICALS, INC. (US) 1996-08-07 EP disclosed
WO-1996012697-A2 CALCIUM RECEPTOR-ACTIVE COMPOUNDS NPS PHARMACEUTICALS, INC. (US) 1996-05-02 WO disclosed
WO-1995011221-A1 CALCIUM RECEPTOR-ACTIVE ARYLALKYL AMINES NPS PHARMACEUTICALS, INC. (US) 1995-04-27 WO disclosed