Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Mycophenolic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IMPDH2 known ✓ | P12268 | 20/20 | 1.00 |
| ▸ | IMPDH1 known ✓ | P20839 | 10/20 | 1.00 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 1.00 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 1.00 |
| ▸ | LMNA | P02545 | 1/20 | 1.00 |
| ▸ | CYP1A2 | P05177 | 1/20 | 1.00 |
| ▸ | CYP3A4 | P08684 | 1/20 | 1.00 |
| ▸ | HPGD | P15428 | 1/20 | 1.00 |
| ▸ | UGT2B7 | P16662 | 1/20 | 1.00 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 1.00 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 1.00 |
| ▸ | HDAC3 | O15379 | 2/20 | 0.79 |
| ▸ | HDAC4 | P56524 | 2/20 | 0.79 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.79 |
| ▸ | HDAC7 | Q8WUI4 | 2/20 | 0.79 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.79 |
| ▸ | HDAC10 | Q969S8 | 2/20 | 0.79 |
| ▸ | HDAC11 | Q96DB2 | 2/20 | 0.79 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.79 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.79 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Mycophenolic Acid SCHEMBL1657813 | 1.00 | IMPDH2 (1.00) | IMPDH2IMPDH1KDM4EALDH1A1LMNA | |
| Mycophenolic Acid SCHEMBL29645054 | 1.00 | IMPDH2 (1.00) | IMPDH2IMPDH1KDM4EALDH1A1LMNA | |
| Mycophenolic Acid SCHEMBL2514376 | 1.00 | IMPDH2 (1.00) | IMPDH2IMPDH1KDM4EALDH1A1LMNA | |
| Mycophenolic Acid SCHEMBL29380425 | 1.00 | IMPDH2 (1.00) | IMPDH2IMPDH1KDM4EALDH1A1LMNA | |
| Mycophenolic Acid SCHEMBL4549 | 1.00 | IMPDH2 (1.00) | IMPDH2IMPDH1KDM4EALDH1A1LMNA | |
| Mycophenolic Acid SCHEMBL5259872 | 1.00 | IMPDH2 (1.00) | IMPDH2IMPDH1KDM4EALDH1A1LMNA | |
| Mycophenolic Acid SCHEMBL5500098 | 1.00 | IMPDH2 (1.00) | IMPDH2IMPDH1KDM4EALDH1A1LMNA | |
| Mycophenolic Acid SCHEMBL6502425 | 0.99 | IMPDH2 (0.98) | IMPDH2IMPDH1KDM4EALDH1A1LMNA | |
| Mycophenolic Acid SCHEMBL3652377 | 0.99 | IMPDH2 (0.98) | IMPDH2IMPDH1KDM4EALDH1A1LMNA | |
| Mycophenolic Acid SCHEMBL1657815 | 0.99 | IMPDH2 (0.98) | IMPDH2IMPDH1KDM4EALDH1A1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 196 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11987804-B2 | Rapamycin resistant cells | SEATTLE CHILDREN'S HOSPITAL (US) | 2024-05-21 | — | — | US | claimed |
| US-20240117008-A1 | METHODS OF EXOGENOUS DRUG ACTIVATION OF CHEMICAL-INDUCED SIGNALING COMPLEXES EXPRESSED IN ENGINEERED CELLS IN VITRO AND IN VIVO | Seattle Children's Hospital (dba Seattle Children's Research Institute) | 2024-04-11 | — | — | US | claimed |
| US-20230416361-A1 | ENGINEERED CD200R ANTIBODIES AND USES THEREOF | OXFORD UNIVERSITY INNOVATION LIMITED (GB) | 2023-12-28 | — | — | US | claimed |
| EP-4267171-A1 | ARTIFICIAL ANTIGEN-SPECIFIC IMMUNOREGULATORY T (AIRT) CELLS | Seattle Children's Hospital (DBA Seattle Children's Research Institute) (US) | 2023-11-01 | — | — | EP | claimed |
| WO-2023196866-A1 | ENGINEERED CD200R ANTIBODIES AND USES THEREOF | MIROBIO LIMITED (GB) | 2023-10-12 | — | — | WO | claimed |
| WO-2022140354-A1 | ARTIFICIAL ANTIGEN-SPECIFIC IMMUNOREGULATORY T (AIRT) CELLS | Seattle Children's Hospital (dba Seattle Children's Research Institute) (US) | 2022-06-30 | — | — | WO | claimed |
| US-20210228629-A1 | ANTI-BCMA CAR-T-CELLS FOR PLASMA CELL DEPLETION | BAYER HEALTHCARE LLC | 2021-07-29 | — | — | US | claimed |
| US-20210069249-A1 | METHODS AND COMPOSITIONS OF CYTOTOXIC T CELL DEPLETION | BAYER HEALTHCARE LLC | 2021-03-11 | — | — | US | claimed |
| EP-3784694-A1 | METHODS AND COMPOSITIONS OF CYTOTOXIC T CELL DEPLETION | CRISPR Therapeutics AG (CH) | 2021-03-03 | — | — | EP | claimed |
| EP-3784259-A1 | RAPAMYCIN RESISTANT CELLS | Seattle Children's Hospital (DBA Seattle Children's Research Institute) (US) | 2021-03-03 | — | — | EP | claimed |
| US-20050203612-A1 | Luminal prostheses which allow for programmed and controlled delivery of mycophenolic acid or derivatives with increased efficacy to selected locations within a patient's vasculature to inhibit restenosis and hyperplasia | AVANTEC VASCULAR CORPORATION (US) | 2005-09-15 | — | — | US | claimed |
| EP-1539041-A1 | DEVICES DELIVERING THERAPEUTIC AGENTS AND METHODS REGARDING THE SAME | Avantec Vascular Corporation (US) | 2005-06-15 | — | — | EP | claimed |
| WO-2005051229-A2 | DEVICES DELIVERING THERAPEUTIC AGENTS AND METHODS REGARDING THE SAME | AVANTEC VASCULAR CORPORATION (US) | 2005-06-09 | — | — | WO | claimed |
| US-20050125054-A1 | Devices delivering therapeutic agents and methods regarding the same | AVANTEC VASCULAR CORPORATION (US) | 2005-06-09 | — | — | US | claimed |
| EP-1536839-A2 | METHOD FOR TREATING DISEASES WITH OMEGA INTERFERON | Intarcia Therapeutics, Inc. (US) | 2005-06-08 | — | — | EP | claimed |
| WO-2004010900-A1 | DEVICES DELIVERING THERAPEUTIC AGENTS AND METHODS REGARDING THE SAME | AVANTEC VASCULAR CORPORATION (US) | 2004-02-05 | — | — | WO | claimed |
| WO-2003063573-A2 | METHOD FOR TREATING DISEASES WITH OMEGA INTERFERON | INTARCIA THERAPEUTICS, INC. (US) | 2003-08-07 | — | — | WO | claimed |
| US-20030143197-A1 | Method for treating diseases with omega interferon | INTARCIA THERAPEUTICS, INC. | 2003-07-31 | — | — | US | claimed |
| US-20030050692-A1 | Delivery of therapeutic capable agents | AVANTEC VASCULAR CORPORATION | 2003-03-13 | — | — | US | claimed |
| WO-2003009777-A2 | DELIVERY OF THERAPEUTIC CAPABLE AGENTS | AVANTEC VASCULAR CORPORATION (US) | 2003-02-06 | — | — | WO | claimed |