Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | F10 | P00742 | 13/20 | 0.55 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.49 |
| ▸ | MALT1 | Q9UDY8 | 1/20 | 0.48 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.47 |
| ▸ | F2 | P00734 | 2/20 | 0.47 |
| ▸ | ELANE | P08246 | 1/20 | 0.47 |
| ▸ | MEN1 | O00255 | 2/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.46 |
| ▸ | USP2 | O75604 | 1/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
| ▸ | TSHR | P16473 | 1/20 | 0.46 |
| ▸ | HTT | P42858 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.46 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.45 |
| ▸ | MAPT | P10636 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2387034 | 0.94 | F10 (0.58) | F10MALT1TRPV1F2ELANE | |
| SCHEMBL2384350 | 0.90 | F10 (0.63) | F10RXFP1F2ELANEMEN1 | |
| SCHEMBL2383853 | 0.82 | LDHA (0.44) | F10TRPV1F2ELANETSHR | |
| SCHEMBL2382772 | 0.81 | TRPV1 (0.49) | TRPV1HSD17B10 | |
| SCHEMBL2384143 | 0.78 | TRPV1 (0.52) | F10TRPV1TSHRHSD17B10ALDH1A1 | |
| SCHEMBL2386175 | 0.78 | TRPV1 (0.47) | TRPV1KDM4EALDH1A1MAPT | |
| SCHEMBL2385630 | 0.78 | ALDH1A1 (0.49) | TRPV1MEN1KMT2AKDM4ELMNA | |
| SCHEMBL2384981 | 0.78 | TRPV1 (0.54) | F10TRPV1 | |
| SCHEMBL2385509 | 0.78 | TRPV1 (0.54) | F10TRPV1 | |
| SCHEMBL2383659 | 0.78 | TRPV1 (0.54) | F10TRPV1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8013156-B2 | Tie-2 modulators and methods of use | EXELIXIS, INC. (US) | 2011-09-06 | — | — | US | disclosed |