Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 8/20 | 0.52 |
| ▸ | MEN1 | O00255 | 7/20 | 0.52 |
| ▸ | MAPT | P10636 | 5/20 | 0.52 |
| ▸ | RAB9A | P51151 | 3/20 | 0.52 |
| ▸ | LMNA | P02545 | 2/20 | 0.52 |
| ▸ | HTT | P42858 | 2/20 | 0.52 |
| ▸ | NPC1 | O15118 | 2/20 | 0.52 |
| ▸ | KCNJ6 | P48051 | 4/20 | 0.47 |
| ▸ | KCNJ3 | P48549 | 4/20 | 0.47 |
| ▸ | KCNJ5 | P48544 | 3/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.46 |
| ▸ | CNR1 | P21554 | 1/20 | 0.46 |
| ▸ | PKM | P14618 | 2/20 | 0.44 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.44 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.44 |
| ▸ | CA1 | P00915 | 2/20 | 0.43 |
| ▸ | CA2 | P00918 | 2/20 | 0.43 |
| ▸ | CA4 | P22748 | 2/20 | 0.43 |
| ▸ | CA7 | P43166 | 2/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12307557 | 0.92 | TSHR (0.45) | KMT2AMEN1MAPTRAB9ALMNA | |
| SCHEMBL12334181 | 0.89 | MAPK13 (0.51) | KMT2AMEN1MAPTRAB9ANPC1 | |
| SCHEMBL12307489 | 0.86 | KMT2A (0.39) | KMT2AMEN1MAPTRAB9ALMNA | |
| SCHEMBL12307644 | 0.85 | KDM4E (0.48) | KMT2AMEN1MAPTRAB9ALMNA | |
| SCHEMBL12307618 | 0.83 | KMT2A (0.45) | KMT2AMEN1MAPTRAB9ALMNA | |
| SCHEMBL12307660 | 0.83 | CACNA1G (0.40) | KMT2AMEN1MAPTLMNAALDH1A1 | |
| SCHEMBL12307639 | 0.83 | KMT2A (0.44) | KMT2AMEN1MAPTRAB9ALMNA | |
| SCHEMBL12307672 | 0.80 | GRM5 (0.44) | KMT2AMEN1MAPTRAB9AHTT | |
| SCHEMBL12307615 | 0.80 | PTGER1 (0.48) | KMT2AMEN1MAPTLMNAHTT | |
| SCHEMBL12307398 | 0.80 | GCK (0.40) | KMT2AMEN1MAPTRAB9AHTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20110230472-A1 | RING-FUSED AZOLE DERIVATIVE HAVING PI3K-INHIBITING ACTIVITY | SHIONOGI & CO., LTD. (JP) | 2011-09-22 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110230472-A1 | RING-FUSED AZOLE DERIVATIVE HAVING PI3K-INHIBITING ACTIVITY | PIK3R5, PIK3R4, PIK3R1 | KMT2A 2170/4885MEN1 1723/4885MAPT 4347/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.