Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK13 | O15264 | 5/20 | 0.51 |
| ▸ | MAPK12 | P53778 | 5/20 | 0.51 |
| ▸ | MAPK11 | Q15759 | 5/20 | 0.51 |
| ▸ | MAPK14 | Q16539 | 5/20 | 0.51 |
| ▸ | KCNJ6 | P48051 | 8/20 | 0.47 |
| ▸ | KCNJ3 | P48549 | 8/20 | 0.47 |
| ▸ | KCNJ5 | P48544 | 6/20 | 0.47 |
| ▸ | TSHR | P16473 | 1/20 | 0.47 |
| ▸ | MAPT | P10636 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.43 |
| ▸ | NPC1 | O15118 | 3/20 | 0.43 |
| ▸ | RAB9A | P51151 | 3/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.43 |
| ▸ | GBA1 | P04062 | 2/20 | 0.43 |
| ▸ | PKM | P14618 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.43 |
| ▸ | DDR2 | Q16832 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12307557 | 0.90 | TSHR (0.45) | MAPK13MAPK12MAPK11MAPK14KCNJ6 | |
| SCHEMBL12307634 | 0.89 | KMT2A (0.52) | KCNJ6KCNJ3KCNJ5MAPTNPC1 | |
| SCHEMBL12334409 | 0.88 | SMN1; SMN2 (0.37) | MAPK13MAPK12MAPK11MAPK14KCNJ6 | |
| SCHEMBL12334420 | 0.83 | ITGB3 (0.40) | MAPK13MAPK12MAPK11MAPK14MAPT | |
| SCHEMBL12307398 | 0.80 | GCK (0.40) | MAPK13MAPK12MAPK11MAPK14KCNJ6 | |
| SCHEMBL12334182 | 0.79 | PARP1 (0.38) | TSHRMAPTKMT2AALDH1A1 | |
| SCHEMBL12307828 | 0.78 | GRM5 (0.41) | MAPK13MAPK12MAPK11MAPK14KCNJ6 | |
| SCHEMBL12307565 | 0.78 | MAPT (0.49) | TSHRMAPTSMN1; SMN2NPC1RAB9A | |
| SCHEMBL12307489 | 0.77 | KMT2A (0.39) | MAPTSMN1; SMN2NPC1RAB9AKMT2A | |
| SCHEMBL12307530 | 0.76 | MEN1 (0.34) | MAPTSMN1; SMN2KMT2AMEN1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20110230472-A1 | RING-FUSED AZOLE DERIVATIVE HAVING PI3K-INHIBITING ACTIVITY | SHIONOGI & CO., LTD. (JP) | 2011-09-22 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110230472-A1 | RING-FUSED AZOLE DERIVATIVE HAVING PI3K-INHIBITING ACTIVITY | PIK3R5, PIK3R4, PIK3R1 | MAPK13 89/4885MAPK12 119/4885MAPK11 201/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.