Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | THRB | P10828 | 19/20 | 0.58 |
| ▸ | THRA | P10827 | 15/20 | 0.58 |
| ▸ | RORC | P51449 | 4/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12312718 | 0.87 | THRB (0.55) | THRBTHRARORC | |
| SCHEMBL12312519 | 0.84 | THRB (0.49) | THRBTHRARORC | |
| SCHEMBL12312518 | 0.84 | THRB (0.58) | THRBTHRARORC | |
| SCHEMBL12312737 | 0.82 | THRB (0.61) | THRBTHRARORC | |
| SCHEMBL12312633 | 0.80 | THRB (0.55) | THRBTHRA | |
| SCHEMBL12312724 | 0.79 | THRB (0.44) | THRBTHRARORC | |
| SCHEMBL12312738 | 0.79 | THRB (0.43) | THRBTHRARORC | |
| SCHEMBL12312622 | 0.79 | THRB (0.50) | THRBTHRA | |
| SCHEMBL12312627 | 0.79 | THRB (0.46) | THRBTHRAALDH1A1 | |
| SCHEMBL12312741 | 0.78 | THRB (0.64) | THRBTHRARORC |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8263659-B2 | Thyroid receptor ligands | BRISTOL-MYERS SQUIBB COMPANY (US) | 2012-09-11 | — | — | US | disclosed |
| US-20100298276-A1 | THYROID RECEPTOR LIGANDS | BRISTOL-MYERS SQUIBB COMPANY | 2010-11-25 | — | — | US | disclosed |
| US-7557143-B2 | Thyroid receptor ligands | BRISTOL-MYERS SQUIBB COMPANY (US) | 2009-07-07 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100298276-A1 | THYROID RECEPTOR LIGANDS | TSHR, THRA, THRB | THRB 3/4885THRA 2/4885RORC 607/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.