Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | S1PR1 | P21453 | 19/20 | 1.00 |
| ▸ | S1PR3 | Q99500 | 10/20 | 1.00 |
| ▸ | S1PR4 | O95977 | 1/20 | 0.70 |
| ▸ | S1PR5 | Q9H228 | 1/20 | 0.70 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23374910 | 1.00 | S1PR1 (1.00) | S1PR1S1PR3S1PR4S1PR5 | |
| SCHEMBL15477948 | 1.00 | S1PR1 (1.00) | S1PR1S1PR3S1PR4S1PR5 | |
| SCHEMBL12315641 | 0.87 | S1PR1 (1.00) | S1PR1S1PR3 | |
| SCHEMBL25991009 | 0.87 | S1PR1 (0.80) | S1PR1S1PR3S1PR4S1PR5 | |
| SCHEMBL12315653 | 0.86 | S1PR1 (1.00) | S1PR1S1PR3S1PR4S1PR5 | |
| SCHEMBL25991073 | 0.85 | S1PR1 (0.76) | S1PR1S1PR3S1PR4S1PR5 | |
| SCHEMBL12315630 | 0.85 | S1PR1 (1.00) | S1PR1S1PR3 | |
| SCHEMBL15477925 | 0.84 | S1PR1 (0.79) | S1PR1S1PR3S1PR4S1PR5 | |
| SCHEMBL22860900 | 0.84 | S1PR1 (0.92) | S1PR1S1PR3S1PR4S1PR5 | |
| SCHEMBL23395208 | 0.84 | S1PR1 (0.78) | S1PR1S1PR3S1PR4S1PR5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 28 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20240368094-A1 | POLYMORPHS OF PONESIMOD | TEVA API INDIA PRIVATE LTD (IN) | 2024-11-07 | — | — | US | disclosed |
| EP-4387960-A1 | POLYMORPHS OF PONESIMOD | Teva Czech Industries s.r.o (CZ) | 2024-06-26 | — | — | EP | disclosed |
| WO-2023152691-A1 | PROCESS FOR THE PREPARATION OF PONESIMOD AND ITS INTERMEDIATES THEREOF | METROCHEM API PVT LTD (IN) | 2023-08-17 | — | — | WO | disclosed |
| WO-2023022896-A1 | POLYMORPHS OF PONESIMOD | TEVA CZECH INDUSTRIES S.R.O (CZ) | 2023-02-23 | — | — | WO | disclosed |
| US-11014940-B1 | Thiazolidinone and oxazolidinone compounds and formulations | CELGENE CORPORATION (US) | 2021-05-25 | — | — | US | disclosed |
| US-11014940-B1 | Thiazolidinone and oxazolidinone compounds and formulations | CELGENE CORPORATION (US) | 2021-05-25 | — | — | US | disclosed |
| EP-2885266-B1 | PROCESS FOR THE PREPARATION OF (2Z,5Z)-5-(3-CHLORO-4-((R)-2,3-DIHYDROXYPROPOXY)BENZYLIDENE)-2-(PROPYLIMINO)-3-(O-TOLYL)THIAZOLIDIN-4-ONE AND INTERMEDIATE USED IN SAID PROCESS | ACTELION PHARMACEUTICALS LTD (CH) | 2020-03-18 | — | — | EP | disclosed |
| US-9340518-B2 | Process for the preparation of (2Z,5Z)-5-(3-chloro-4-((R)-2,3-dihydroxypropdxy)benzylidene)-2-(propylimino)-3-(o-tolyl)thiazolidin-4-one and intermediate used in said process | ACTELION PHARMACEUTICALS LTD. (CH) | 2016-05-17 | — | — | US | disclosed |
| US-9340518-B2 | Process for the preparation of (2Z,5Z)-5-(3-chloro-4-((R)-2,3-dihydroxypropdxy)benzylidene)-2-(propylimino)-3-(o-tolyl)thiazolidin-4-one and intermediate used in said process | ACTELION PHARMACEUTICALS LTD. (CH) | 2016-05-17 | — | — | US | disclosed |
| US-9340518-B2 | Process for the preparation of (2Z,5Z)-5-(3-chloro-4-((R)-2,3-dihydroxypropdxy)benzylidene)-2-(propylimino)-3-(o-tolyl)thiazolidin-4-one and intermediate used in said process | ACTELION PHARMACEUTICALS LTD. (CH) | 2016-05-17 | — | — | US | disclosed |
| EP-2094676-B1 | NEW PROCESS FOR THE PREPARATION OF 2-IMINOTHIAZOLIDIN-4-ONE DERIVATIVES | ACTELION PHARMACEUTICALS LTD (CH) | 2013-04-10 | — | — | EP | disclosed |
| US-20120302758-A1 | NEW PROCESS FOR THE PREPARATION OF 2-IMINO-THIAZOLIDIN-4-ONE DERIVATIVES | VANDA PHARMACEUTICALS INC. | 2012-11-29 | — | — | US | disclosed |
| US-20120302758-A1 | NEW PROCESS FOR THE PREPARATION OF 2-IMINO-THIAZOLIDIN-4-ONE DERIVATIVES | VANDA PHARMACEUTICALS INC. | 2012-11-29 | — | — | US | disclosed |
| US-8263780-B2 | Process for the preparation of 2-imino-thiazolidin-4-one derivatives | ACTELION PHARMACEUTICALS LTD. (CH) | 2012-09-11 | — | — | US | disclosed |
| US-8263780-B2 | Process for the preparation of 2-imino-thiazolidin-4-one derivatives | ACTELION PHARMACEUTICALS LTD. (CH) | 2012-09-11 | — | — | US | disclosed |
| US-20110201821-A2 | NEW PROCESS FOR THE PREPARATION OF 2-IMINO-THIAZOLIDIN-4-ONE DERIVATES | VANDA PHARMACEUTICALS INC. | 2011-08-18 | — | — | US | disclosed |
| US-20110201821-A2 | NEW PROCESS FOR THE PREPARATION OF 2-IMINO-THIAZOLIDIN-4-ONE DERIVATES | VANDA PHARMACEUTICALS INC. | 2011-08-18 | — | — | US | disclosed |
| US-20100317867-A1 | NEW PROCESS FOR THE PREPARATION OF 2-IMINO-THIAZOLIDIN-4-ONE DERIVATIVES | ACTELION PHARMACEUTICALS LTD. (CH) | 2010-12-16 | — | — | US | disclosed |
| US-20100317867-A1 | NEW PROCESS FOR THE PREPARATION OF 2-IMINO-THIAZOLIDIN-4-ONE DERIVATIVES | ACTELION PHARMACEUTICALS LTD. (CH) | 2010-12-16 | — | — | US | disclosed |
| WO-2008062376-A2 | NEW PROCESS FOR THE PREPARATION OF 2-IMINO-THIAZOLIDIN-4-ONE DERIVATIVES | ACTELION PHARMACEUTICALS LTD (CH) | 2008-05-29 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100317867-A1 | NEW PROCESS FOR THE PREPARATION OF 2-IMINO-THIAZOLIDIN-4-ONE DERIVATIVES | IL4, IL15, IL2 | S1PR1 3394/4885S1PR3 3399/4885S1PR4 1967/4885 |
| US-20240368094-A1 | POLYMORPHS OF PONESIMOD | HLA-DRB1, PON1, HDLBP | S1PR1 337/4885S1PR3 351/4885S1PR4 121/4885 |
| US-20110201821-A2 | NEW PROCESS FOR THE PREPARATION OF 2-IMINO-THIAZOLIDIN-4-ONE DERIVATES | IL4, IL2, IL15 | S1PR1 3355/4885S1PR3 3539/4885S1PR4 2154/4885 |
| US-11014940-B1 | Thiazolidinone and oxazolidinone compounds and formulations | IL17A, OXA1L, ACOX1 | S1PR1 1435/4885S1PR3 1974/4885S1PR4 1618/4885 |
| US-20120302758-A1 | NEW PROCESS FOR THE PREPARATION OF 2-IMINO-THIAZOLIDIN-4-ONE DERIVATIVES | IL4, IL15, IL2 | S1PR1 3394/4885S1PR3 3399/4885S1PR4 1967/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.