Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Cefuroxime. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 8/20 | 0.98 |
| ▸ | HSD17B10 | Q99714 | 4/20 | 0.98 |
| ▸ | NR1I2 | O75469 | 4/20 | 0.98 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.98 |
| ▸ | PGR | P06401 | 1/20 | 0.98 |
| ▸ | TSHR | P16473 | 1/20 | 0.98 |
| ▸ | MAPT | P10636 | 7/20 | 0.84 |
| ▸ | POLB | P06746 | 2/20 | 0.84 |
| ▸ | PKM | P14618 | 2/20 | 0.84 |
| ▸ | CTDSP1 | Q9GZU7 | 2/20 | 0.84 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.84 |
| ▸ | ABCC4 | O15439 | 2/20 | 0.77 |
| ▸ | PDE4A | P27815 | 1/20 | 0.77 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.62 |
| ▸ | SLC22A6 | Q4U2R8 | 2/20 | 0.58 |
| ▸ | SLC22A8 | Q8TCC7 | 2/20 | 0.58 |
| ▸ | SLC22A11 | Q9NSA0 | 2/20 | 0.58 |
| ▸ | ALB | P02768 | 1/20 | 0.58 |
| ▸ | PPARG | P37231 | 1/20 | 0.58 |
| ▸ | HTR2C | P28335 | 1/20 | 0.57 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Cefuroxime SCHEMBL41261 | 1.00 | TDP1 (0.98) | TDP1HSD17B10NR1I2ALDH1A1PGR | |
| Cefuroxime SCHEMBL4137312 | 1.00 | TDP1 (0.98) | TDP1HSD17B10NR1I2ALDH1A1PGR | |
| Cefuroxime SCHEMBL10907122 | 0.99 | TDP1 (1.00) | TDP1HSD17B10NR1I2ALDH1A1PGR | |
| Cefuroxime SCHEMBL20535121 | 0.99 | TDP1 (1.00) | TDP1HSD17B10NR1I2ALDH1A1PGR | |
| Cefuroxime SCHEMBL40415 | 0.99 | TDP1 (1.00) | TDP1HSD17B10NR1I2ALDH1A1PGR | |
| Cefuroxime SCHEMBL1821942 | 0.99 | TDP1 (1.00) | TDP1HSD17B10NR1I2ALDH1A1PGR | |
| Cefuroxime SCHEMBL11243712 | 0.99 | TDP1 (1.00) | TDP1HSD17B10NR1I2ALDH1A1PGR | |
| Cefuroxime SCHEMBL3861498 | 0.99 | TDP1 (1.00) | TDP1HSD17B10NR1I2ALDH1A1PGR | |
| Cefuroxime SCHEMBL2221559 | 0.99 | TDP1 (1.00) | TDP1HSD17B10NR1I2ALDH1A1PGR | |
| Cefuroxime SCHEMBL11549178 | 0.99 | TDP1 (1.00) | TDP1HSD17B10NR1I2ALDH1A1PGR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 145 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-120037191-A | Freeze-drying process preparation method of sodium cefuroxime axetil powder injection for injection | 浙江惠迪森药业有限公司 | 2025-05-27 | — | — | CN | claimed |
| CN-119139246-A | Cephalosporium oxydanum freeze-dried powder for injection and preparation method thereof | 成都倍特药业股份有限公司 | 2024-12-17 | — | — | CN | claimed |
| CN-117069739-A | Preparation method of high-purity sodium cefuroxime axetil | 山西千岫制药有限公司 | 2023-11-17 | — | — | CN | claimed |
| CN-116296745-A | Method for detecting impurities in sodium cefuroxime axetil freeze-dried powder for injection | 杭州沐源生物医药科技有限公司 | 2023-06-23 | — | — | CN | claimed |
| CN-109456339-A | A kind of synthetic method of Cefuroxime Sodium | 湖北凌晟药业有限公司 | 2019-03-12 | — | — | CN | claimed |
| CN-108926570-A | Cephalosporin analog antibiotic is preparing the application in preventing/treating pulmonary hypertension drug | 上海颢峰医药科技有限公司 | 2018-12-04 | — | — | CN | claimed |
| CN-101721379-B | Cefuroxime sodium suspension powder injection | HAINAN MEILANSHIKE PHARMA CO | 2011-02-02 | — | — | CN | claimed |
| CN-101721379-A | cefuroxime sodium suspension powder injection | HAINAN MEILANSHIKE PHARMACEUTI | 2010-06-09 | — | — | CN | claimed |
| US-4775750-A | Process for preparing sodium cefuroxime | GLAXO GROUP LIMITED (GB) | 1988-10-04 | — | — | US | claimed |
| US-4298732-A | Crystallization process | GLAXO GROUP LIMITED (GB) | 1981-11-03 | — | — | US | claimed |
| US-4277601-A | Preparation of sodium cefuroxime | GLAXO GROUP LIMITED (GB) | 1981-07-07 | — | — | US | claimed |
| JP-55111490-A | — | — | None | — | — | JP | disclosed |
| JP-60075485-A | — | — | None | — | — | JP | disclosed |
| US-20250197401-A1 | PURINONE DERIVATIVE | ONO PHARMACEUTICAL CO., LTD. (JP) | 2025-06-19 | — | — | US | disclosed |
| CN-120037191-A | Freeze-drying process preparation method of sodium cefuroxime axetil powder injection for injection | 浙江惠迪森药业有限公司 | 2025-05-27 | — | — | CN | disclosed |
| US-4277601-A | Preparation of sodium cefuroxime | GLAXO GROUP LIMITED (GB) | 1981-07-07 | — | — | US | disclosed |
| US-4277601-A | Preparation of sodium cefuroxime | GLAXO GROUP LIMITED (GB) | 1981-07-07 | — | — | US | disclosed |
| US-4277601-A | Preparation of sodium cefuroxime | GLAXO GROUP LIMITED (GB) | 1981-07-07 | — | — | US | disclosed |
| JP-S55111490-A | IMPROVEMENT ON MANUFACTURE OF SODIUM CEFUROXIME | GLAXO GROUP LTD | 1980-08-28 | — | — | JP | disclosed |
| US-4128715-A | LYSINE SALT OF CERFUROXIME | GLAXO LABORATORIES LIMITED (GB) | 1978-12-05 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20250197401-A1 | PURINONE DERIVATIVE | BTK, KIT, SYK | TDP1 1653/4885HSD17B10 3011/4885NR1I2 431/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.