Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Cefuroxime. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 8/20 | 0.98 |
| ▸ | HSD17B10 | Q99714 | 4/20 | 0.98 |
| ▸ | NR1I2 | O75469 | 4/20 | 0.98 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.98 |
| ▸ | PGR | P06401 | 1/20 | 0.98 |
| ▸ | TSHR | P16473 | 1/20 | 0.98 |
| ▸ | MAPT | P10636 | 7/20 | 0.84 |
| ▸ | POLB | P06746 | 2/20 | 0.84 |
| ▸ | PKM | P14618 | 2/20 | 0.84 |
| ▸ | CTDSP1 | Q9GZU7 | 2/20 | 0.84 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.84 |
| ▸ | ABCC4 | O15439 | 2/20 | 0.77 |
| ▸ | PDE4A | P27815 | 1/20 | 0.77 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.62 |
| ▸ | SLC22A6 | Q4U2R8 | 2/20 | 0.58 |
| ▸ | SLC22A8 | Q8TCC7 | 2/20 | 0.58 |
| ▸ | SLC22A11 | Q9NSA0 | 2/20 | 0.58 |
| ▸ | ALB | P02768 | 1/20 | 0.58 |
| ▸ | PPARG | P37231 | 1/20 | 0.58 |
| ▸ | HTR2C | P28335 | 1/20 | 0.57 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Cefuroxime SCHEMBL123194 | 1.00 | TDP1 (0.98) | TDP1HSD17B10NR1I2ALDH1A1PGR | |
| Cefuroxime SCHEMBL4137312 | 1.00 | TDP1 (0.98) | TDP1HSD17B10NR1I2ALDH1A1PGR | |
| Cefuroxime SCHEMBL11243712 | 0.99 | TDP1 (1.00) | TDP1HSD17B10NR1I2ALDH1A1PGR | |
| Cefuroxime SCHEMBL11549178 | 0.99 | TDP1 (1.00) | TDP1HSD17B10NR1I2ALDH1A1PGR | |
| Cefuroxime SCHEMBL1821942 | 0.99 | TDP1 (1.00) | TDP1HSD17B10NR1I2ALDH1A1PGR | |
| Cefuroxime SCHEMBL40413 | 0.99 | TDP1 (1.00) | TDP1HSD17B10NR1I2ALDH1A1PGR | |
| Cefuroxime SCHEMBL40415 | 0.99 | TDP1 (1.00) | TDP1HSD17B10NR1I2ALDH1A1PGR | |
| Cefuroxime SCHEMBL3861498 | 0.99 | TDP1 (1.00) | TDP1HSD17B10NR1I2ALDH1A1PGR | |
| Cefuroxime SCHEMBL20535121 | 0.99 | TDP1 (1.00) | TDP1HSD17B10NR1I2ALDH1A1PGR | |
| Cefuroxime SCHEMBL10907122 | 0.99 | TDP1 (1.00) | TDP1HSD17B10NR1I2ALDH1A1PGR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Appears in 3962 patents — a generic fragment claimed broadly, so it's down-weighted as IP noise. Top by claim status then date:
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-120054294-A | Preparation system and method for cefuroxime sodium crystal transformation | 广东立国制药有限公司 | 2025-05-30 | — | — | CN | claimed |
| CN-120037191-A | Freeze-drying process preparation method of sodium cefuroxime axetil powder injection for injection | 浙江惠迪森药业有限公司 | 2025-05-27 | — | — | CN | claimed |
| US-12274830-B2 | Nitric oxide inhalation therapy for infants with bronchiolitis | BEYOND AIR LTD (IL) | 2025-04-15 | — | — | US | claimed |
| CN-119799555-A | Aerobic denitrification ceramic bacterium LT9 and application thereof | 河北科技大学 | 2025-04-11 | — | — | CN | claimed |
| CN-119776224-A | Drug-resistant pseudomonas aeruginosa and application thereof | 昆明理工大学 | 2025-04-08 | — | — | CN | claimed |
| CN-119563608-A | Pretreatment method and preservation method of sterilizing liquid and same-kind valved pipelines | 中国医学科学院阜外医院 | 2025-03-07 | — | — | CN | claimed |
| CN-119372112-A | Aerobic denitrification halomonas hydrophila LHT6 and application thereof | 河北科技大学 | 2025-01-28 | — | — | CN | claimed |
| CN-115445232-B | Ultrasonic-reinforced symmetrical jet-flow coupling slug flow crystallization system device and application thereof | 天津大学 | 2025-01-14 | — | — | CN | claimed |
| CN-118994198-B | Recycling method of cefuroxime sodium mother liquor | 山东信立泰药业有限公司 | 2025-01-10 | — | — | CN | claimed |
| CN-119139246-A | Cephalosporium oxydanum freeze-dried powder for injection and preparation method thereof | 成都倍特药业股份有限公司 | 2024-12-17 | — | — | CN | claimed |
| WO-2002030469-A2 | BETA-LACTAM ANTIBIOTIC-POLYSACCHARIDE COMPLEX | ORCHID CHEMICALS AND PHARMACEUTICALS LIMITED (IN) | 2002-04-18 | — | — | WO | claimed |
| WO-2002016372-A1 | NEW METHOD FOR PREPARATION OF AMORPHOUS CEFUROXIME AXETIL | CHOONGWAE PHARMA CORPORATION (KR) | 2002-02-28 | — | — | WO | claimed |
| US-20020004071-A1 | Rapid-melt semi-solid compositions, methods of making same and methods of using same | CAPRICORN PHARMA, INC. | 2002-01-10 | — | — | US | claimed |
| WO-2002002080-A1 | RAPID-MELT SEMI-SOLID COMPOSITIONS, METHODS OF MAKING SAME AND METHODS OF USING SAME | CAPRICORN PHARMA, INC. (US) | 2002-01-10 | — | — | WO | claimed |
| US-6245735-B1 | CONJUGATE OF ANTIBIOTIC AND POLYPEPTIDE OF CYSTIC FIBROSIS TRANSMEMBRANE CONDUCTANCE REGULATOR OR LIPOPOLYSACCHARIDE BINDING FRAGMENT | THE BRIGHAM AND WOMEN'S HOSPITAL, INC. | 2001-06-12 | — | — | US | claimed |
| US-5811547-A | Method for inducing crystalline state transition in medicinal substance | NIPPON SHINYAJU CO., LTD. (JP) | 1998-09-22 | — | — | US | claimed |
| US-5498787-A | Method for preparing cephalosporin derivatives | STANDARD CHEMICAL & PHARMACEUTICAL CO., LTD. (TW) | 1996-03-12 | — | — | US | claimed |
| US-4775750-A | Process for preparing sodium cefuroxime | GLAXO GROUP LIMITED (GB) | 1988-10-04 | — | — | US | claimed |
| US-4298732-A | Crystallization process | GLAXO GROUP LIMITED (GB) | 1981-11-03 | — | — | US | claimed |
| US-4277601-A | Preparation of sodium cefuroxime | GLAXO GROUP LIMITED (GB) | 1981-07-07 | — | — | US | claimed |