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Cefuroxime

Cefuroxime

SCHEMBL4137312

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nearest known ligand 0.98

Full drug profile on Sugi Atlas →

Known targets — ChEMBL curated mechanism

dacAdacBdacCftsImrcAmrcBmrdA

The experimentally established mechanism targets of Cefuroxime. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ TDP1 Q9NUW8 8/20 0.98
▸ HSD17B10 Q99714 4/20 0.98
▸ NR1I2 O75469 4/20 0.98
▸ ALDH1A1 P00352 2/20 0.98
▸ PGR P06401 1/20 0.98
▸ TSHR P16473 1/20 0.98
▸ MAPT P10636 7/20 0.84
▸ POLB P06746 2/20 0.84
▸ PKM P14618 2/20 0.84
▸ CTDSP1 Q9GZU7 2/20 0.84
▸ MAPK1 P28482 1/20 0.84
▸ ABCC4 O15439 2/20 0.77
▸ PDE4A P27815 1/20 0.77
▸ KMT2A Q03164 1/20 0.62
▸ SLC22A6 Q4U2R8 2/20 0.58
▸ SLC22A8 Q8TCC7 2/20 0.58
▸ SLC22A11 Q9NSA0 2/20 0.58
▸ ALB P02768 1/20 0.58
▸ PPARG P37231 1/20 0.58
▸ HTR2C P28335 1/20 0.57

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Cefuroxime SCHEMBL123194 1.00 TDP1 (0.98) TDP1HSD17B10NR1I2ALDH1A1PGR
Cefuroxime SCHEMBL41261 1.00 TDP1 (0.98) TDP1HSD17B10NR1I2ALDH1A1PGR
Cefuroxime SCHEMBL11243712 0.99 TDP1 (1.00) TDP1HSD17B10NR1I2ALDH1A1PGR
Cefuroxime SCHEMBL11549178 0.99 TDP1 (1.00) TDP1HSD17B10NR1I2ALDH1A1PGR
Cefuroxime SCHEMBL1821942 0.99 TDP1 (1.00) TDP1HSD17B10NR1I2ALDH1A1PGR
Cefuroxime SCHEMBL40413 0.99 TDP1 (1.00) TDP1HSD17B10NR1I2ALDH1A1PGR
Cefuroxime SCHEMBL40415 0.99 TDP1 (1.00) TDP1HSD17B10NR1I2ALDH1A1PGR
Cefuroxime SCHEMBL3861498 0.99 TDP1 (1.00) TDP1HSD17B10NR1I2ALDH1A1PGR
Cefuroxime SCHEMBL20535121 0.99 TDP1 (1.00) TDP1HSD17B10NR1I2ALDH1A1PGR
Cefuroxime SCHEMBL10907122 0.99 TDP1 (1.00) TDP1HSD17B10NR1I2ALDH1A1PGR

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-8426373-B2 Stable pharmaceutical composition comprising beta-lactam antibiotic and ion-chelating agent ZHANG HESHENG (CN) 2013-04-23 — — US disclosed
EP-2500023-A1 Antibiotics composition comprising beta-lactam antibiotic, beta-lactamase inhibitor, and buffer component Tianjin Hemay Bio-Tech Co., Ltd. (CN) 2012-09-19 — — EP disclosed
US-20090156518-A1 STABLE PHARMACEUTICAL COMPOSITION COMPRISING BETA-LACTAM ANTIBIOTIC AND BUFFER ZHANG HESHENG 2009-06-18 — — US disclosed
US-20090155387-A1 STABLE PHARMACEUTICAL COMPOSITION COMPRISING BETA-LACTAM ANTIBIOTIC AND ION-CHELATING AGENT ZHANG HESHENG 2009-06-18 — — US disclosed
EP-2062582-A1 THE ANTIBIOTICS COMPOSITION COMPRISING BETA-LACTAM ANTIBIOTICS AND BUFFERS Tianjin Hemey Bio-Tech Co., Ltd. (CN) 2009-05-27 — — EP disclosed
EP-2062581-A1 THE ANTIBIOTICS COMPOSITION COMPRISING BETA-LACTAM ANTIBIOTICS AND IONIC CHELATING AGENTS Tianjin Hemey Bio-Tech Co., Ltd. (CN) 2009-05-27 — — EP disclosed