Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH3 | Q9Y5N1 | 5/20 | 0.42 |
| ▸ | HRH4 | Q9H3N8 | 3/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | GLA | P06280 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.42 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.42 |
| ▸ | THPO | P40225 | 1/20 | 0.42 |
| ▸ | ITGB2 | P05107 | 2/20 | 0.42 |
| ▸ | ICAM1 | P05362 | 2/20 | 0.42 |
| ▸ | ITGAL | P20701 | 2/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.42 |
| ▸ | SLC7A5 | Q01650 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | APEX1 | P27695 | 1/20 | 0.41 |
| ▸ | BLM | P54132 | 1/20 | 0.41 |
| ▸ | CPB2 | Q96IY4 | 1/20 | 0.40 |
| ▸ | REN | P00797 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12322755 | 0.89 | HRH3 (0.43) | HRH3HRH4ALDH1A1MEN1GLA | |
| SCHEMBL19483449 | 0.80 | CYP3A4 (0.47) | HRH3HRH4ALDH1A1MEN1GLA | |
| SCHEMBL19483446 | 0.80 | CYP3A4 (0.47) | HRH3HRH4ALDH1A1MEN1GLA | |
| SCHEMBL8906903 | 0.77 | HRH3 (0.47) | HRH3HRH4ITGB2ICAM1ITGAL | |
| SCHEMBL12323344 | 0.76 | HRH4 (0.49) | HRH3HRH4ALDH1A1MEN1GLA | |
| SCHEMBL23387015 | 0.75 | HRH3 (0.47) | HRH3HRH4ALDH1A1MEN1GLA | |
| SCHEMBL14961160 | 0.75 | ITGB2 (0.49) | HRH3HRH4ALDH1A1MEN1GLA | |
| SCHEMBL14961161 | 0.75 | ITGB2 (0.49) | HRH3HRH4ALDH1A1MEN1GLA | |
| SCHEMBL10001165 | 0.74 | CYP3A4 (0.51) | ITGB2ICAM1ITGALCYP3A4SLC7A5 | |
| SCHEMBL22957034 | 0.74 | HRH3 (0.44) | HRH3HRH4ALDH1A1MEN1GLA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011119871-A1 | RNA INTERFERENCE IN OCULAR INDICATIONS | RXI PHRMACEUTICALS CORPORATION (US) | 2011-09-29 | — | — | WO | disclosed |
| WO-2011119852-A1 | REDUCED SIZE SELF-DELIVERING RNAI COMPOUNDS | RXI PHARMACEUTICALS CORPORATION (US) | 2011-09-29 | — | — | WO | disclosed |