Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 6/20 | 0.51 |
| ▸ | LMNA | P02545 | 5/20 | 0.51 |
| ▸ | MEN1 | O00255 | 5/20 | 0.51 |
| ▸ | MAPT | P10636 | 5/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.51 |
| ▸ | HTT | P42858 | 4/20 | 0.51 |
| ▸ | GAA | P10253 | 3/20 | 0.51 |
| ▸ | NPSR1 | Q6W5P4 | 3/20 | 0.51 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.51 |
| ▸ | POLB | P06746 | 2/20 | 0.51 |
| ▸ | HPGD | P15428 | 1/20 | 0.51 |
| ▸ | RECQL | P46063 | 1/20 | 0.51 |
| ▸ | EGFR | P00533 | 4/20 | 0.50 |
| ▸ | BTK | Q06187 | 4/20 | 0.50 |
| ▸ | JAK3 | P52333 | 6/20 | 0.49 |
| ▸ | MITF | O75030 | 1/20 | 0.49 |
| ▸ | NOD2 | Q9HC29 | 1/20 | 0.49 |
| ▸ | JAK1 | P23458 | 4/20 | 0.49 |
| ▸ | BRD4 | O60885 | 3/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13868445 | 0.89 | BRD4 (0.54) | ALDH1A1SMN1; SMN2LMNAMEN1MAPT | |
| SCHEMBL17915964 | 0.88 | ALDH1A1 (0.54) | ALDH1A1SMN1; SMN2LMNAMEN1MAPT | |
| SCHEMBL17915905 | 0.87 | KDM4E (0.54) | ALDH1A1SMN1; SMN2LMNAMEN1MAPT | |
| SCHEMBL24124309 | 0.86 | JAK3 (0.57) | ALDH1A1SMN1; SMN2LMNAMEN1MAPT | |
| SCHEMBL270236 | 0.85 | BRD4 (0.54) | ALDH1A1SMN1; SMN2LMNAMEN1MAPT | |
| SCHEMBL301185 | 0.85 | ALDH1A1 (0.52) | ALDH1A1SMN1; SMN2LMNAMEN1MAPT | |
| SCHEMBL10260766 | 0.84 | KDM4E (0.52) | ALDH1A1SMN1; SMN2LMNAMEN1MAPT | |
| SCHEMBL270240 | 0.84 | BRD4 (0.55) | ALDH1A1SMN1; SMN2LMNAMEN1MAPT | |
| SCHEMBL264344 | 0.82 | BRD4 (0.69) | EGFRBTKJAK3JAK1BRD4 | |
| SCHEMBL30270574 | 0.81 | EGFR (0.56) | EGFRBTKJAK3JAK1BRD4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20110212077-A1 | BI-ARYL META-PYRIMIDINE INHIBITORS OF KINASES | TARGEGEN, INC. (US) | 2011-09-01 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110212077-A1 | BI-ARYL META-PYRIMIDINE INHIBITORS OF KINASES | JAK2, TYK2, JAK3 | ALDH1A1 3235/4885SMN1; SMN2 4746/4885LMNA 4817/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.