Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRD4 | O60885 | 6/20 | 0.54 |
| ▸ | JAK3 | P52333 | 7/20 | 0.53 |
| ▸ | JAK1 | P23458 | 6/20 | 0.53 |
| ▸ | JAK2 | O60674 | 6/20 | 0.53 |
| ▸ | EGFR | P00533 | 4/20 | 0.53 |
| ▸ | BTK | Q06187 | 4/20 | 0.53 |
| ▸ | RET | P07949 | 3/20 | 0.53 |
| ▸ | WEE1 | P30291 | 3/20 | 0.53 |
| ▸ | FLT3 | P36888 | 3/20 | 0.53 |
| ▸ | ALK | Q9UM73 | 3/20 | 0.53 |
| ▸ | SYK | P43405 | 3/20 | 0.53 |
| ▸ | AXL | P30530 | 3/20 | 0.53 |
| ▸ | BRDT | Q58F21 | 2/20 | 0.53 |
| ▸ | PLK4 | O00444 | 2/20 | 0.53 |
| ▸ | CHEK1 | O14757 | 2/20 | 0.53 |
| ▸ | AURKA | O14965 | 2/20 | 0.53 |
| ▸ | DCLK1 | O15075 | 2/20 | 0.53 |
| ▸ | DAPK3 | O43293 | 2/20 | 0.53 |
| ▸ | ROCK2 | O75116 | 2/20 | 0.53 |
| ▸ | PAK4 | O96013 | 2/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13868446 | 0.92 | BRD4 (0.60) | BRD4JAK3JAK1JAK2EGFR | |
| SCHEMBL12320856 | 0.89 | ALDH1A1 (0.51) | BRD4JAK3JAK1JAK2EGFR | |
| SCHEMBL264344 | 0.86 | BRD4 (0.69) | BRD4JAK3JAK1JAK2EGFR | |
| SCHEMBL24124309 | 0.85 | JAK3 (0.57) | BRD4JAK3JAK1JAK2EGFR | |
| SCHEMBL17915964 | 0.85 | ALDH1A1 (0.54) | BRD4JAK3JAK1JAK2EGFR | |
| SCHEMBL17915905 | 0.84 | KDM4E (0.54) | BRD4JAK3JAK1JAK2EGFR | |
| SCHEMBL270236 | 0.82 | BRD4 (0.54) | BRD4JAK3JAK1JAK2EGFR | |
| SCHEMBL301185 | 0.82 | ALDH1A1 (0.52) | BRD4JAK3JAK1JAK2EGFR | |
| SCHEMBL13868200 | 0.82 | BRD4 (0.79) | BRD4JAK3JAK1JAK2EGFR | |
| SCHEMBL13868227 | 0.82 | BRD4 (0.77) | BRD4JAK3JAK1JAK2RET |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7528143-B2 | Bi-aryl meta-pyrimidine inhibitors of kinases | TARGEGEN, INC. (US) | 2009-05-05 | — | — | US | disclosed |
| US-20070191405-A1 | Bi-aryl meta-pyrimidine inhibitors of kinases | TARGEGEN, INC. (US) | 2007-08-16 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070191405-A1 | Bi-aryl meta-pyrimidine inhibitors of kinases | JAK2, TYK2, JAK3 | BRD4 142/4885JAK3 3/4885JAK1 4/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.