Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AKT1 | P31749 | 12/20 | 0.44 |
| ▸ | AKT3 | Q9Y243 | 12/20 | 0.44 |
| ▸ | AKT2 | P31751 | 11/20 | 0.44 |
| ▸ | HTR1A | P08908 | 1/20 | 0.35 |
| ▸ | SLC6A3 | Q01959 | 2/20 | 0.33 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.33 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.33 |
| ▸ | TP53 | P04637 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.32 |
| ▸ | PANK3 | Q9H999 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14304014 | 0.90 | AKT3 (0.54) | AKT1AKT3AKT2 | |
| SCHEMBL12323932 | 0.89 | AKT3 (0.49) | AKT1AKT3AKT2CYP1A2CYP3A4 | |
| SCHEMBL8226975 | 0.85 | AKT1 (0.46) | AKT1AKT3AKT2 | |
| SCHEMBL14310839 | 0.79 | AKT3 (0.55) | AKT1AKT3AKT2CYP1A2CYP3A4 | |
| SCHEMBL12324605 | 0.79 | AKT3 (0.46) | AKT1AKT3AKT2CYP1A2CYP3A4 | |
| SCHEMBL8224124 | 0.78 | AKT1 (0.59) | AKT1AKT3AKT2 | |
| SCHEMBL8226943 | 0.78 | AKT3 (0.46) | AKT1AKT3AKT2 | |
| SCHEMBL12323943 | 0.77 | AKT3 (0.43) | AKT1AKT3AKT2 | |
| SCHEMBL8223678 | 0.76 | AKT1 (0.40) | AKT1AKT3AKT2 | |
| SCHEMBL8226097 | 0.76 | AKT3 (0.55) | AKT1AKT3AKT2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008006040-A1 | HYDROXYLATED AND METHOXYLATED CYCLOPENTA [D] PYRIMIDINES AS AKT PROTEIN KINASE INHIBITORS | ARRAY BIOPHARMA INC. (US) | 2008-01-10 | — | — | WO | disclosed |