Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.44 |
| ▸ | MAPT | P10636 | 1/20 | 0.44 |
| ▸ | CASR | P41180 | 1/20 | 0.42 |
| ▸ | CTSV | O60911 | 1/20 | 0.41 |
| ▸ | CTSL | P07711 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 2/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.39 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.39 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.39 |
| ▸ | PARP15 | Q460N3 | 1/20 | 0.38 |
| ▸ | PARP14 | Q460N5 | 1/20 | 0.38 |
| ▸ | PARP10 | Q53GL7 | 1/20 | 0.38 |
| ▸ | TNKS2 | Q9H2K2 | 1/20 | 0.38 |
| ▸ | PARP2 | Q9UGN5 | 1/20 | 0.38 |
| ▸ | SERPINE1 | P05121 | 1/20 | 0.36 |
| ▸ | NPBWR1 | P48145 | 1/20 | 0.36 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12323824 | 0.91 | KDM4E (0.43) | KDM4EALDH1A1MAPTCTSVCTSL | |
| SCHEMBL2431267 | 0.91 | KDM4E (0.50) | KDM4EALDH1A1MAPTCTSVCTSL | |
| SCHEMBL2434345 | 0.86 | KDM4E (0.49) | KDM4EALDH1A1MAPTCTSVCTSL | |
| SCHEMBL2425579 | 0.86 | KDM4E (0.46) | KDM4EALDH1A1MAPTCTSVCTSL | |
| SCHEMBL2464274 | 0.85 | KDM4E (0.41) | KDM4EALDH1A1MAPTCTSVCTSL | |
| SCHEMBL12324341 | 0.83 | KDM4E (0.44) | KDM4EALDH1A1MAPTCTSVCTSL | |
| SCHEMBL14860434 | 0.83 | KDM4E (0.40) | KDM4EALDH1A1MAPTCTSVCTSL | |
| SCHEMBL14867326 | 0.82 | ATM (0.39) | KDM4EALDH1A1MAPTCTSVCTSL | |
| SCHEMBL14859622 | 0.80 | KDM4E (0.41) | KDM4EALDH1A1MAPTCTSVCTSL | |
| SCHEMBL2430827 | 0.80 | CTSV (0.47) | KDM4EALDH1A1MAPTCTSVCTSL |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011107709-A1 | USE OF ISOQUINOLONES FOR PREPARING DRUGS, NOVEL ISOQUINOLONES AND METHOD FOR SYNTHESISING SAME | UNIVERSITE JOSEPH FOURIER (FR) | 2011-09-09 | — | — | WO | disclosed |