Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.46 |
| ▸ | MAPT | P10636 | 4/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.46 |
| ▸ | CLK1 | P49759 | 1/20 | 0.43 |
| ▸ | GSK3B | P49841 | 1/20 | 0.43 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.43 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.43 |
| ▸ | DYRK1B | Q9Y463 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.43 |
| ▸ | MEN1 | O00255 | 3/20 | 0.43 |
| ▸ | TP53 | P04637 | 2/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.43 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.43 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.43 |
| ▸ | HPGD | P15428 | 2/20 | 0.43 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.43 |
| ▸ | CTSV | O60911 | 1/20 | 0.43 |
| ▸ | CTSL | P07711 | 1/20 | 0.43 |
| ▸ | SERPINE1 | P05121 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2431267 | 0.93 | KDM4E (0.50) | KDM4EMAPTALDH1A1GSK3BDYRK1A | |
| SCHEMBL2434345 | 0.88 | KDM4E (0.49) | KDM4EMAPTALDH1A1GSK3BKMT2A | |
| SCHEMBL12323824 | 0.86 | KDM4E (0.43) | KDM4EMAPTALDH1A1KMT2AMEN1 | |
| SCHEMBL12323933 | 0.86 | KDM4E (0.44) | KDM4EMAPTALDH1A1KMT2AMEN1 | |
| SCHEMBL12324341 | 0.85 | KDM4E (0.44) | KDM4EMAPTALDH1A1GSK3BKMT2A | |
| SCHEMBL2430827 | 0.84 | CTSV (0.47) | KDM4EMAPTALDH1A1KMT2AMEN1 | |
| SCHEMBL14860434 | 0.83 | KDM4E (0.40) | KDM4EMAPTALDH1A1KMT2AMEN1 | |
| SCHEMBL14867326 | 0.82 | ATM (0.39) | KDM4EMAPTALDH1A1KMT2AMEN1 | |
| SCHEMBL14859622 | 0.82 | KDM4E (0.41) | KDM4EMAPTALDH1A1GSK3BDYRK1A | |
| SCHEMBL12323798 | 0.81 | PARP1 (0.48) | KDM4EMAPTALDH1A1KMT2AHPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2542239-B1 | USE OF ISOQUINOLONES FOR PREPARING DRUGS, NOVEL ISOQUINOLONES AND METHOD FOR SYNTHESISING SAME | Université Joseph Fourier (FR) | 2015-11-11 | — | — | EP | disclosed |
| EP-2542239-B1 | USE OF ISOQUINOLONES FOR PREPARING DRUGS, NOVEL ISOQUINOLONES AND METHOD FOR SYNTHESISING SAME | Université Joseph Fourier (FR) | 2015-11-11 | — | — | EP | disclosed |
| US-8883763-B2 | Use of isoquinolones for preparing drugs, novel isoquinolones and method for synthesising same | UNIVERSITE JOSEPH FOURIER (FR) | 2014-11-11 | — | — | US | disclosed |
| US-8883763-B2 | Use of isoquinolones for preparing drugs, novel isoquinolones and method for synthesising same | UNIVERSITE JOSEPH FOURIER (FR) | 2014-11-11 | — | — | US | disclosed |
| US-8883763-B2 | Use of isoquinolones for preparing drugs, novel isoquinolones and method for synthesising same | UNIVERSITE JOSEPH FOURIER (FR) | 2014-11-11 | — | — | US | disclosed |
| US-20130096083-A1 | USE OF ISOQUINOLONES FOR PREPARING DRUGS, NOVEL ISOQUINOLONES AND METHOD FOR SYNTHESISING SAME | UNIVERSITE JOSEPH FOURIER (FR) | 2013-04-18 | — | — | US | disclosed |
| US-20130096083-A1 | USE OF ISOQUINOLONES FOR PREPARING DRUGS, NOVEL ISOQUINOLONES AND METHOD FOR SYNTHESISING SAME | UNIVERSITE JOSEPH FOURIER (FR) | 2013-04-18 | — | — | US | disclosed |
| US-20130096083-A1 | USE OF ISOQUINOLONES FOR PREPARING DRUGS, NOVEL ISOQUINOLONES AND METHOD FOR SYNTHESISING SAME | UNIVERSITE JOSEPH FOURIER (FR) | 2013-04-18 | — | — | US | disclosed |
| EP-2542239-A1 | USE OF ISOQUINOLONES FOR PREPARING DRUGS, NOVEL ISOQUINOLONES AND METHOD FOR SYNTHESISING SAME | Université Joseph Fourier (FR) | 2013-01-09 | — | — | EP | disclosed |
| WO-2011107709-A1 | USE OF ISOQUINOLONES FOR PREPARING DRUGS, NOVEL ISOQUINOLONES AND METHOD FOR SYNTHESISING SAME | UNIVERSITE JOSEPH FOURIER (FR) | 2011-09-09 | — | — | WO | disclosed |
| WO-2011107709-A1 | USE OF ISOQUINOLONES FOR PREPARING DRUGS, NOVEL ISOQUINOLONES AND METHOD FOR SYNTHESISING SAME | UNIVERSITE JOSEPH FOURIER (FR) | 2011-09-09 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20130096083-A1 | USE OF ISOQUINOLONES FOR PREPARING DRUGS, NOVEL ISOQUINOLONES AND METHOD FOR SYNTHESISING SAME | GNAQ, HCCS, SDHA | KDM4E 1796/4885MAPT 4086/4885ALDH1A1 2507/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.