Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | APAF1 | O14727 | 2/20 | 0.73 |
| ▸ | TDO2 | P48775 | 15/20 | 0.67 |
| ▸ | IDO2 | Q6ZQW0 | 11/20 | 0.67 |
| ▸ | IDO1 | P14902 | 16/20 | 0.65 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.52 |
| ▸ | MEN1 | O00255 | 2/20 | 0.52 |
| ▸ | NPC1 | O15118 | 2/20 | 0.52 |
| ▸ | RAB9A | P51151 | 2/20 | 0.52 |
| ▸ | MITF | O75030 | 1/20 | 0.52 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.52 |
| ▸ | LMNA | P02545 | 1/20 | 0.49 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.49 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.49 |
| ▸ | MAPT | P10636 | 1/20 | 0.49 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.49 |
| ▸ | HTT | P42858 | 1/20 | 0.49 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.49 |
| ▸ | NTRK2 | Q16620 | 1/20 | 0.49 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL26858212 | 0.87 | TDO2 (0.70) | APAF1TDO2IDO2IDO1KMT2A | |
| SCHEMBL4587567 | 0.86 | APAF1 (0.71) | APAF1TDO2IDO2IDO1KMT2A | |
| SCHEMBL9103054 | 0.85 | TDO2 (0.85) | APAF1TDO2IDO2IDO1KMT2A | |
| SCHEMBL9100596 | 0.84 | APAF1 (1.00) | APAF1TDO2IDO2IDO1KMT2A | |
| SCHEMBL4585230 | 0.84 | IDO1 (0.83) | APAF1TDO2IDO2IDO1KMT2A | |
| SCHEMBL9101181 | 0.83 | TDO2 (0.74) | APAF1TDO2IDO2IDO1KMT2A | |
| SCHEMBL9115670 | 0.82 | IDO1 (0.72) | APAF1TDO2IDO2IDO1KMT2A | |
| SCHEMBL26614103 | 0.81 | IDO1 (0.75) | APAF1TDO2IDO2IDO1KMT2A | |
| SCHEMBL30639105 | 0.81 | IDO1 (0.75) | APAF1TDO2IDO2IDO1KMT2A | |
| SCHEMBL12290014 | 0.80 | APAF1 (0.59) | APAF1TDO2IDO2IDO1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8012987-B2 | Indolo[2,1-b] quinazole-6,12-dione antimalarial compounds and methods of treating malaria therewith | THE UNITED STATES OF AMERICA AS REPRESENTED BY THE SECRETARY OF THE ARMY (US) | 2011-09-06 | — | — | US | disclosed |