Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ROCK2 | O75116 | 13/20 | 0.46 |
| ▸ | GBA1 | P04062 | 1/20 | 0.38 |
| ▸ | UGCG | Q16739 | 1/20 | 0.38 |
| ▸ | GBA2 | Q9HCG7 | 1/20 | 0.38 |
| ▸ | ROCK1 | Q13464 | 7/20 | 0.37 |
| ▸ | MCHR1 | Q99705 | 2/20 | 0.37 |
| ▸ | GPR6 | P46095 | 1/20 | 0.36 |
| ▸ | PRKCZ | Q05513 | 1/20 | 0.35 |
| ▸ | PRKD2 | Q9BZL6 | 1/20 | 0.35 |
| ▸ | JAK2 | O60674 | 1/20 | 0.35 |
| ▸ | JAK1 | P23458 | 1/20 | 0.35 |
| ▸ | CCR2 | P41597 | 2/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12326775 | 0.87 | ROCK2 (0.45) | ROCK2ROCK1GPR6PRKCZPRKD2 | |
| SCHEMBL2422015 | 0.84 | ROCK2 (0.49) | ROCK2ROCK1GPR6PRKCZPRKD2 | |
| SCHEMBL13087219 | 0.84 | SLC6A7 (0.46) | ROCK2GPR6 | |
| SCHEMBL12327362 | 0.82 | ROCK2 (0.40) | ROCK2ROCK1MCHR1GPR6PRKCZ | |
| SCHEMBL12327341 | 0.82 | ROCK2 (0.45) | ROCK2ROCK1MCHR1GPR6PRKCZ | |
| SCHEMBL2427691 | 0.81 | ROCK2 (0.48) | ROCK2ROCK1MCHR1GPR6PRKCZ | |
| SCHEMBL2425776 | 0.81 | ROCK2 (0.56) | ROCK2GBA1ROCK1JAK2JAK1 | |
| SCHEMBL2427707 | 0.81 | ROCK2 (0.49) | ROCK2ROCK1GPR6PRKCZPRKD2 | |
| SCHEMBL2422828 | 0.80 | ROCK2 (0.48) | ROCK2ROCK1MCHR1GPR6PRKCZ | |
| SCHEMBL13087174 | 0.80 | ROCK2 (0.44) | ROCK2GPR6PRKCZPRKD2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2366699-A1 | 8-SUBSTITUTED ISOQUINOLINE DERIVATIVE AND USE THEREOF | Asahi Kasei Pharma Corporation (JP) | 2011-09-21 | — | — | EP | disclosed |