Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IKBKB | O14920 | 9/20 | 0.64 |
| ▸ | CHUK | O15111 | 8/20 | 0.64 |
| ▸ | ROCK1 | Q13464 | 3/20 | 0.64 |
| ▸ | LCK | P06239 | 2/20 | 0.64 |
| ▸ | HRH1 | P35367 | 1/20 | 0.50 |
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.49 |
| ▸ | MKNK2 | Q9HBH9 | 1/20 | 0.49 |
| ▸ | AKT1 | P31749 | 1/20 | 0.46 |
| ▸ | PRKCZ | Q05513 | 4/20 | 0.46 |
| ▸ | PRKD2 | Q9BZL6 | 3/20 | 0.46 |
| ▸ | SYK | P43405 | 3/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13442191 | 0.93 | IKBKB (0.55) | IKBKBCHUKROCK1LCKHRH1 | |
| SCHEMBL2424475 | 0.86 | IKBKB (0.51) | IKBKBCHUKROCK1LCKHRH1 | |
| SCHEMBL12327902 | 0.86 | IKBKB (0.51) | IKBKBCHUKROCK1LCKHRH1 | |
| SCHEMBL13440921 | 0.85 | IKBKB (0.69) | IKBKBCHUKROCK1LCKHRH1 | |
| SCHEMBL13442183 | 0.82 | IKBKB (0.51) | IKBKBCHUKROCK1LCKMKNK1 | |
| SCHEMBL13440925 | 0.82 | IKBKB (0.53) | IKBKBCHUKROCK1LCKHRH1 | |
| SCHEMBL13442184 | 0.81 | IKBKB (0.49) | IKBKBCHUKROCK1LCKMKNK1 | |
| SCHEMBL2426936 | 0.80 | IKBKB (0.54) | IKBKBCHUKROCK1LCKHRH1 | |
| SCHEMBL13087653 | 0.79 | IKBKB (0.56) | IKBKBCHUKROCK1LCK | |
| SCHEMBL13087965 | 0.79 | IKBKB (0.54) | IKBKBCHUKROCK1LCKAKT1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2366699-A1 | 8-SUBSTITUTED ISOQUINOLINE DERIVATIVE AND USE THEREOF | Asahi Kasei Pharma Corporation (JP) | 2011-09-21 | — | — | EP | disclosed |
| WO-2010038465-A1 | 8-SUBSTITUTED ISOQUINOLINE DERIVATIVE AND USE THEREOF | 旭化成ファーマ株式会社 (JP) | 2010-04-08 | — | — | WO | disclosed |