Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IKBKB | O14920 | 8/20 | 0.51 |
| ▸ | CHUK | O15111 | 7/20 | 0.51 |
| ▸ | ROCK1 | Q13464 | 5/20 | 0.51 |
| ▸ | LCK | P06239 | 2/20 | 0.51 |
| ▸ | TNF | P01375 | 1/20 | 0.46 |
| ▸ | AKT1 | P31749 | 1/20 | 0.43 |
| ▸ | MKNK1 | Q9BUB5 | 2/20 | 0.41 |
| ▸ | MKNK2 | Q9HBH9 | 2/20 | 0.41 |
| ▸ | PRKCZ | Q05513 | 2/20 | 0.38 |
| ▸ | ATR | Q13535 | 1/20 | 0.36 |
| ▸ | PIM1 | P11309 | 2/20 | 0.36 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.36 |
| ▸ | CDC42BPB | Q9Y5S2 | 1/20 | 0.36 |
| ▸ | PIM3 | Q86V86 | 1/20 | 0.35 |
| ▸ | PIM2 | Q9P1W9 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13442184 | 0.90 | IKBKB (0.49) | IKBKBCHUKROCK1LCKTNF | |
| SCHEMBL13440925 | 0.89 | IKBKB (0.53) | IKBKBCHUKROCK1LCKTNF | |
| SCHEMBL13442191 | 0.85 | IKBKB (0.55) | IKBKBCHUKROCK1LCKAKT1 | |
| SCHEMBL12326819 | 0.82 | IKBKB (0.64) | IKBKBCHUKROCK1LCKAKT1 | |
| SCHEMBL13087893 | 0.82 | IKBKB (0.42) | IKBKBCHUKROCK1LCKTNF | |
| SCHEMBL13088170 | 0.82 | IKBKB (0.44) | IKBKBCHUKTNFATR | |
| SCHEMBL13088196 | 0.82 | IKBKB (0.53) | IKBKBCHUKROCK1LCKTNF | |
| SCHEMBL2424475 | 0.80 | IKBKB (0.51) | IKBKBCHUKROCK1LCKAKT1 | |
| SCHEMBL13440921 | 0.78 | IKBKB (0.69) | IKBKBCHUKROCK1LCKAKT1 | |
| SCHEMBL12327249 | 0.75 | IKBKB (0.43) | IKBKBCHUKROCK1LCKAKT1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010038465-A1 | 8-SUBSTITUTED ISOQUINOLINE DERIVATIVE AND USE THEREOF | 旭化成ファーマ株式会社 (JP) | 2010-04-08 | — | — | WO | disclosed |