Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IKBKB | O14920 | 10/20 | 0.53 |
| ▸ | CHUK | O15111 | 9/20 | 0.53 |
| ▸ | ROCK1 | Q13464 | 3/20 | 0.48 |
| ▸ | LCK | P06239 | 2/20 | 0.48 |
| ▸ | MKNK1 | Q9BUB5 | 2/20 | 0.43 |
| ▸ | MKNK2 | Q9HBH9 | 2/20 | 0.43 |
| ▸ | TNF | P01375 | 1/20 | 0.41 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.40 |
| ▸ | AKT1 | P31749 | 1/20 | 0.39 |
| ▸ | HRH1 | P35367 | 1/20 | 0.38 |
| ▸ | PIM1 | P11309 | 3/20 | 0.38 |
| ▸ | PIM3 | Q86V86 | 2/20 | 0.38 |
| ▸ | PIM2 | Q9P1W9 | 2/20 | 0.38 |
| ▸ | SYK | P43405 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13442183 | 0.89 | IKBKB (0.51) | IKBKBCHUKROCK1LCKMKNK1 | |
| SCHEMBL13440921 | 0.87 | IKBKB (0.69) | IKBKBCHUKROCK1LCKMKNK1 | |
| SCHEMBL2424475 | 0.86 | IKBKB (0.51) | IKBKBCHUKROCK1LCKMKNK1 | |
| SCHEMBL13087950 | 0.83 | IKBKB (0.54) | IKBKBCHUKTNFLRRK2 | |
| SCHEMBL13087895 | 0.83 | IKBKB (0.44) | IKBKBCHUKTNFLRRK2 | |
| SCHEMBL13087922 | 0.83 | IKBKB (0.46) | IKBKBCHUKTNFLRRK2 | |
| SCHEMBL15172428 | 0.83 | PRKCZ (0.46) | IKBKBCHUKTNF | |
| SCHEMBL12326819 | 0.82 | IKBKB (0.64) | IKBKBCHUKROCK1LCKMKNK1 | |
| SCHEMBL13442184 | 0.82 | IKBKB (0.49) | IKBKBCHUKROCK1LCKMKNK1 | |
| SCHEMBL12327902 | 0.80 | IKBKB (0.51) | IKBKBCHUKROCK1LCKMKNK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010038465-A1 | 8-SUBSTITUTED ISOQUINOLINE DERIVATIVE AND USE THEREOF | 旭化成ファーマ株式会社 (JP) | 2010-04-08 | — | — | WO | disclosed |