Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ROCK2 | O75116 | 2/20 | 0.44 |
| ▸ | ROCK1 | Q13464 | 2/20 | 0.44 |
| ▸ | CDC42BPB | Q9Y5S2 | 1/20 | 0.44 |
| ▸ | PRKD1 | Q15139 | 1/20 | 0.43 |
| ▸ | BRD4 | O60885 | 3/20 | 0.43 |
| ▸ | ATAD2 | Q6PL18 | 3/20 | 0.43 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.41 |
| ▸ | IKBKB | O14920 | 1/20 | 0.41 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.41 |
| ▸ | PRKCZ | Q05513 | 7/20 | 0.41 |
| ▸ | PRKD2 | Q9BZL6 | 5/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.41 |
| ▸ | LATS1 | O95835 | 1/20 | 0.41 |
| ▸ | LATS2 | Q9NRM7 | 1/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.41 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.41 |
| ▸ | USP2 | O75604 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.40 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15172430 | 0.81 | PRKCZ (0.43) | ROCK2ROCK1CDC42BPBPRKD1BRD4 | |
| SCHEMBL12327354 | 0.81 | PRKCZ (0.62) | ROCK2ROCK1CDC42BPBIKBKBPRKCZ | |
| SCHEMBL13440618 | 0.80 | PRKCZ (0.47) | ROCK2ROCK1CDC42BPBPRKD1BRD4 | |
| Hydrochloric Acid SCHEMBL23360683 | 0.80 | PRKCZ (0.48) | ROCK2ROCK1CDC42BPBBRD4ATAD2 | |
| SCHEMBL13440633 | 0.79 | PRKCZ (0.44) | ROCK2ROCK1CDC42BPBPRKD1BRD4 | |
| SCHEMBL13090107 | 0.79 | PRKCZ (0.44) | ROCK2ROCK1CDC42BPBPRKD1BRD4 | |
| SCHEMBL15172427 | 0.79 | PRKCZ (0.44) | ROCK2ROCK1CDC42BPBPRKD1PRKCZ | |
| Hydrochloric Acid SCHEMBL23360436 | 0.78 | ROCK2 (0.57) | ROCK2ROCK1CDC42BPBBRD4ATAD2 | |
| Hydrochloric Acid SCHEMBL29862734 | 0.78 | ROCK2 (0.57) | ROCK2ROCK1CDC42BPBBRD4ATAD2 | |
| SCHEMBL15172382 | 0.77 | BRD4 (0.46) | ROCK2ROCK1CDC42BPBBRD4ATAD2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2366699-A1 | 8-SUBSTITUTED ISOQUINOLINE DERIVATIVE AND USE THEREOF | Asahi Kasei Pharma Corporation (JP) | 2011-09-21 | — | — | EP | disclosed |