Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GHSR | Q92847 | 20/20 | 0.52 |
| ▸ | CHRM2 | P08172 | 8/20 | 0.52 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.42 |
| ▸ | HTR2B | P41595 | 1/20 | 0.42 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12329331 | 0.89 | GHSR (0.54) | GHSRCHRM2CYP3A4HTR2BKCNH2 | |
| SCHEMBL15603793 | 0.88 | GHSR (0.52) | GHSRCHRM2CYP3A4HTR2BKCNH2 | |
| SCHEMBL12329096 | 0.86 | GHSR (0.64) | GHSRCHRM2CYP3A4HTR2BKCNH2 | |
| SCHEMBL2443443 | 0.85 | GHSR (0.53) | GHSRCHRM2CYP3A4HTR2BKCNH2 | |
| SCHEMBL2475710 | 0.85 | GHSR (0.53) | GHSRCHRM2CYP3A4HTR2BKCNH2 | |
| SCHEMBL2436649 | 0.85 | GHSR (0.57) | GHSRCHRM2CYP3A4HTR2BKCNH2 | |
| SCHEMBL12299437 | 0.84 | GHSR (0.55) | GHSRCHRM2CYP3A4HTR2BKCNH2 | |
| SCHEMBL2438302 | 0.80 | GHSR (0.76) | GHSRCHRM2CYP3A4HTR2BKCNH2 | |
| SCHEMBL12328040 | 0.79 | GHSR (0.49) | GHSRCHRM2CYP3A4HTR2BKCNH2 | |
| SCHEMBL2441577 | 0.78 | GHSR (0.79) | GHSRCHRM2CYP3A4HTR2BKCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011114271-A1 | 2,3 DIHYDRO-1H-INDEN-1-YL- 2,7-DIAZASPIRO [3.6] NONANE DERIVATIVES AND THEIR USE AS ANTAGONISTS OR INVERSE AGONISTS OF THE GHRELIN RECEPTOR | PFIZER INC. (US) | 2011-09-22 | — | — | WO | disclosed |