Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 1/20 | 0.66 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.66 |
| ▸ | PTGFR | P43088 | 1/20 | 0.55 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.55 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.55 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.55 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.55 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.55 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.55 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.55 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.55 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.55 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.55 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.55 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.55 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.55 |
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 0.55 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 0.55 |
| ▸ | TBXAS1 | P24557 | 7/20 | 0.54 |
| ▸ | LTB4R | Q15722 | 5/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25170050 | 1.00 | MAPT (0.66) | MAPTRXFP1PTGFRHDAC3MAPK1 | |
| SCHEMBL7512732 | 0.98 | MAPT (0.62) | MAPTRXFP1PTGFRHDAC3MAPK1 | |
| SCHEMBL10290715 | 0.93 | SMN1; SMN2 (0.63) | MAPTRXFP1PTGFRHDAC3MAPK1 | |
| SCHEMBL1197247 | 0.91 | MAPT (0.78) | MAPTRXFP1HDAC3MAPK1ADRA1A | |
| SCHEMBL711512 | 0.90 | MAPT (0.66) | MAPTRXFP1HDAC11PPARGPPARA | |
| SCHEMBL25173309 | 0.90 | MAPT (0.66) | MAPTRXFP1HDAC11PPARGPPARA | |
| Hexanoate SCHEMBL28378377 | 0.89 | MAPT (0.64) | MAPTRXFP1HDAC11PPARGPPARA | |
| SCHEMBL19248516 | 0.88 | MAPT (0.62) | MAPTRXFP1HDAC3MAPK1ADRA1A | |
| SCHEMBL3674500 | 0.86 | KEAP1 (0.61) | PTGFRHDAC3MAPK1ADRA1AHDAC4 | |
| SCHEMBL27578485 | 0.85 | MAPT (0.68) | MAPTRXFP1HDAC3MAPK1ADRA1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1954668-B1 | HOMO- AND HETEROCYCLIC COMPOUNDS SUITABLE AS CETP INHIBITORS | BRISTOL MYERS SQUIBB CO (US) | 2011-09-28 | — | — | EP | disclosed |