SCHEMBL1233320

SCHEMBL1233320

Cc1ccc(C(=O)Nc2ccon2)cc1

nearest known ligand 0.65

Predicted protein targets (top 19)

geneUniProtsupporting neighboursconfidence
RAB9A P51151 6/20 0.65
POLB P06746 2/20 0.65
SMN1; SMN2 Q16637 7/20 0.62
ALDH1A1 P00352 4/20 0.59
L3MBTL1 Q9Y468 1/20 0.59
KDM4E B2RXH2 2/20 0.57
HTT P42858 2/20 0.57
HPGD P15428 2/20 0.57
NPC1 O15118 3/20 0.57
LMNA P02545 1/20 0.57
TSHR P16473 2/20 0.56
TP53 P04637 1/20 0.51
NFKB1 P19838 1/20 0.51
NFKB2 Q00653 1/20 0.51
RELA Q04206 1/20 0.51
GAA P10253 1/20 0.51
KMT2A Q03164 2/20 0.51
MEN1 O00255 1/20 0.51
PYGM P11217 1/20 0.51

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL29348787 0.83 KMT2A (0.57) RAB9ASMN1; SMN2ALDH1A1L3MBTL1KDM4E
SCHEMBL5550226 0.83 SMN1; SMN2 (0.60) RAB9APOLBSMN1; SMN2ALDH1A1L3MBTL1
SCHEMBL11277786 0.83 SMN1; SMN2 (0.68) RAB9ASMN1; SMN2ALDH1A1L3MBTL1KDM4E
SCHEMBL28321600 0.81 SMN1; SMN2 (0.70) RAB9APOLBSMN1; SMN2L3MBTL1KDM4E
SCHEMBL20332878 0.81 SMN1; SMN2 (0.55) RAB9ASMN1; SMN2ALDH1A1L3MBTL1KDM4E
SCHEMBL3890906 0.80 SMN1; SMN2 (0.62) RAB9APOLBSMN1; SMN2ALDH1A1L3MBTL1
SCHEMBL1233477 0.79 SMN1; SMN2 (0.58) RAB9ASMN1; SMN2ALDH1A1L3MBTL1KDM4E
SCHEMBL5070509 0.79 SMN1; SMN2 (0.58) RAB9ASMN1; SMN2ALDH1A1L3MBTL1KDM4E
SCHEMBL29477055 0.79 SMN1; SMN2 (0.58) RAB9ASMN1; SMN2ALDH1A1L3MBTL1KDM4E
SCHEMBL22468550 0.79 SMN1; SMN2 (0.58) RAB9ASMN1; SMN2ALDH1A1L3MBTL1KDM4E

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2020198053-A1 2-OXO-2,3-DIHYDRO-1H-IMIDAZO[4,5-B]PYRIDIN-6-YL)-4-METHYLBENZAMIDE DERIVATIVES AND SIMILAR COMPOUNDS AS RIPK2 INHIBITORS FOR TREATING E.G. AUTOIMMUNE DISEASES TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) 2020-10-01 WO claimed
EP-2334674-A1 PYRIDAZINO- PYRIDINONE COMPOUNDS FOR THE TREATMENT OF PROTEIN KINASE MEDIATED DISEASES. Amgen, Inc (US) 2011-06-22 EP claimed
WO-2010025201-A1 PYRIDAZINO- PYRIDINONE COMPOUNDS FOR THE TREATMENT OF PROTEIN KINASE MEDIATED DISEASES. AMGEN INC. (US) 2010-03-04 WO claimed
EP-2280943-A1 NEW SUBSTITUTED SPIROÝCYCLOALKYL-1,3'-INDOL¨-2'(1'H)-ONE DERIVATIVES AND THEIR USE AS P38 MITOGEN-ACTIVATED KINASE INHIBITORS. Almirall, S.A. (ES) 2011-02-09 EP disclosed
WO-2009124692-A1 NEW SUBSTITUTED SPIRO[CYCLOALKYL-1,3'-INDOL]-2'(1'H)-ONE DERIVATIVES AND THEIR USE AS P38 MITOGEN-ACTIVATED KINASE INHIBITORS. ALMIRALL, S.A. (ES) 2009-10-15 WO disclosed