Sugi Predict

Sugi Predict / Compounds / SCHEMBL11277786

SCHEMBL11277786

SCHEMBL11277786

O=C(Nc1ccon1)c1ccccc1

nearest known ligand 0.68

Predicted protein targets (top 16)

geneUniProtsupporting neighboursconfidence
▸ SMN1; SMN2 Q16637 7/20 0.68
▸ TSHR P16473 2/20 0.68
▸ GAA P10253 1/20 0.62
▸ KMT2A Q03164 6/20 0.58
▸ MEN1 O00255 3/20 0.58
▸ RAB9A P51151 3/20 0.57
▸ NPC1 O15118 2/20 0.57
▸ KDM4E B2RXH2 3/20 0.56
▸ HPGD P15428 3/20 0.56
▸ HTT P42858 2/20 0.56
▸ ALDH1A1 P00352 5/20 0.56
▸ LMNA P02545 2/20 0.56
▸ L3MBTL1 Q9Y468 1/20 0.54
▸ USP2 O75604 1/20 0.53
▸ MAPK1 P28482 1/20 0.53
▸ HSD17B10 Q99714 1/20 0.53

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL29348787 0.83 KMT2A (0.57) SMN1; SMN2TSHRGAAKMT2AMEN1
SCHEMBL5550226 0.83 SMN1; SMN2 (0.60) SMN1; SMN2TSHRGAAKMT2AMEN1
SCHEMBL17538518 0.81 SMN1; SMN2 (0.70) SMN1; SMN2TSHRGAAKMT2AMEN1
SCHEMBL1353809 0.81 SMN1; SMN2 (0.70) SMN1; SMN2TSHRGAAKMT2AMEN1
SCHEMBL28321600 0.81 SMN1; SMN2 (0.70) SMN1; SMN2TSHRKMT2AMEN1RAB9A
SCHEMBL20332878 0.80 SMN1; SMN2 (0.55) SMN1; SMN2TSHRGAAKMT2ARAB9A
Hydrochloric Acid SCHEMBL31753014 0.80 SMN1; SMN2 (0.68) SMN1; SMN2TSHRGAAKMT2AMEN1
SCHEMBL3009475 0.79 — —
SCHEMBL5511173 0.76 SMN1; SMN2 (0.48) SMN1; SMN2TSHRGAAKMT2AMEN1
SCHEMBL10352012 0.76 SMN1; SMN2 (0.67) SMN1; SMN2TSHRGAAKMT2AMEN1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 23 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2015193229-A1 BET-PROTEIN INHIBITING 1,4-DIHYDROPYRIDO[3,4-B]PYRAZINONES WITH META-SUBSTITUTED AROMATIC AMINO- OR ETHER GROUPS BAYER PHARMA AKTIENGESELLSCHAFT (DE) 2015-12-23 — — WO claimed
EP-2925322-A1 INHIBITORS OF THE RENAL OUTER MEDULLARY POTASSIUM CHANNEL Merck Sharp & Dohme Corp. (US) 2015-10-07 — — EP claimed
WO-2014085210-A1 INHIBITORS OF THE RENAL OUTER MEDULLARY POTASSIUM CHANNEL MERCK SHARP & DOHME CORP. (US) 2014-06-05 — — WO claimed
CN-109535153-A Benzisothiazolinone isoxazole acetamide derivative and synthetic method and application thereof 南京工业大学 2019-03-29 — — CN disclosed
EP-2791119-B1 N-(1,2,5-OXADIAZOL-3-YL)-, N-(1,3,4-OXADIAZOL-2-YL), N-(TETRAZOL-5-YL)- UND N-(TRIAZOL-5-YL)-ARYL CARBOXYLIC ACID AMIDES AND USE OF SAME AS HERBICIDES BAYER IP GMBH (DE) 2017-02-01 — — EP disclosed
EP-2928874-B1 N-(ISOXAZOL-3-YL)ARYL CARBOXYLIC ACID AMIDES AND USE OF SAME AS HERBICIDES BAYER CROPSCIENCE AG (DE) 2017-02-01 — — EP disclosed
US-9204650-B2 N-(1,2,5-oxadiazol-3-yl)-, N-(1,3,4-oxadiazol-2-yl)-, N-(tetrazol-5-yl)-, and N-(triazol-5-yl) aryl carboxylic acid amides and use thereof as herbicides BAYER INTELLECTUAL PROPERTY GMBH (DE) 2015-12-08 — — US disclosed
US-20140371068-A1 N-(1,2,5-OXADIAZOL-3-YL)-, N-(1,3,4-OXADIAZOL-2-YL)-, N-(TETRAZOL-5-YL)-, AND N-(TRIAZOL-5-YL) ARYL CARBOXYLIC ACID AMIDES AND USE THEREOF AS HERBICIDES BAYER CROPSCIENCE AKTIENGESELLSCHAFT (DE) 2014-12-18 — — US disclosed
EP-2791119-A1 N-(1,2,5-OXADIAZOL-3-YL), N-(1,3,4-OXADIAZOL-2-YL), N-(TETRAZOL-5-YL), AND N-(TRIAZOL-5-YL) ARYL CARBOXYLIC ACID AMIDES AND USE THEREOF AS HERBICIDES Bayer Intellectual Property GmbH (DE) 2014-10-22 — — EP disclosed
CN-103987701-A N-(1,2,5-oxadiazol-3-yl), N-(1,3,4-oxadiazol-2-yl), N-(tetrazol-5-yl), and N-(triazol-5-yl) aryl carboxylic acid amides and use thereof as herbicides BAYER IP GMBH 2014-08-13 — — CN disclosed
WO-2013087577-A1 N-(1,2,5-OXADIAZOL-3-YL), N-(1,3,4-OXADIAZOL-2-YL), N-(TETRAZOL-5-YL), AND N-(TRIAZOL-5-YL) ARYL CARBOXYLIC ACID AMIDES AND USE THEREOF AS HERBICIDES BAYER INTELLECTUAL PROPERTY GMBH (DE) 2013-06-20 — — WO disclosed
US-4112108-A TRANQUILIZER, SLEEP INDUCER SANDOZ, INC. (US) 1978-09-05 — — US disclosed
US-4086243-A Intermediates in the preparation of isoxazolyl benzamides SANDOZ, INC. (US) 1978-04-25 — — US disclosed
US-4086243-A Intermediates in the preparation of isoxazolyl benzamides SANDOZ, INC. (US) 1978-04-25 — — US disclosed
US-4086243-A Intermediates in the preparation of isoxazolyl benzamides SANDOZ, INC. (US) 1978-04-25 — — US disclosed
US-3995048-A Isoxazolyl benzamides useful as tranquilizers and sleep-inducers SANDOZ, INC. (US) 1976-11-30 — — US disclosed
US-3995048-A Isoxazolyl benzamides useful as tranquilizers and sleep-inducers SANDOZ, INC. (US) 1976-11-30 — — US disclosed
US-3995048-A Isoxazolyl benzamides useful as tranquilizers and sleep-inducers SANDOZ, INC. (US) 1976-11-30 — — US disclosed
US-3987179-A ISOXAZOLYL BENZAMIDES AS PHARMACOLOGICAL AGENTS SANDOZ, INC. (US) 1976-10-19 — — US disclosed
US-3987179-A ISOXAZOLYL BENZAMIDES AS PHARMACOLOGICAL AGENTS SANDOZ, INC. (US) 1976-10-19 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20140371068-A1 N-(1,2,5-OXADIAZOL-3-YL)-, N-(1,3,4-OXADIAZOL-2-YL)-, N-(TETRAZOL-5-YL)-, AND N-(TRIAZOL-5-YL) ARYL CARBOXYLIC ACID AMIDES AND USE THEREOF AS HERBICIDES NAT1, MT-CO3, MT-CO1 SMN1; SMN2 3215/4885TSHR 655/4885GAA 1744/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.