Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 2/20 | 0.57 |
| ▸ | SMN1; SMN2 | Q16637 | 6/20 | 0.57 |
| ▸ | RAB9A | P51151 | 3/20 | 0.57 |
| ▸ | HTT | P42858 | 2/20 | 0.57 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.57 |
| ▸ | HPGD | P15428 | 2/20 | 0.57 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.57 |
| ▸ | LMNA | P02545 | 2/20 | 0.57 |
| ▸ | NPC1 | O15118 | 2/20 | 0.57 |
| ▸ | TSHR | P16473 | 1/20 | 0.56 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.51 |
| ▸ | GAA | P10253 | 1/20 | 0.51 |
| ▸ | CCNA2 | P20248 | 3/20 | 0.50 |
| ▸ | CDK2 | P24941 | 3/20 | 0.50 |
| ▸ | CCNA1 | P78396 | 3/20 | 0.50 |
| ▸ | TP53 | P04637 | 2/20 | 0.47 |
| ▸ | MEN1 | O00255 | 1/20 | 0.47 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5550226 | 0.83 | SMN1; SMN2 (0.60) | KMT2ASMN1; SMN2RAB9AHTTKDM4E | |
| SCHEMBL1233320 | 0.83 | RAB9A (0.65) | KMT2ASMN1; SMN2RAB9AHTTKDM4E | |
| SCHEMBL11277786 | 0.83 | SMN1; SMN2 (0.68) | KMT2ASMN1; SMN2RAB9AHTTKDM4E | |
| SCHEMBL20332878 | 0.81 | SMN1; SMN2 (0.55) | KMT2ASMN1; SMN2RAB9AHTTKDM4E | |
| SCHEMBL29477055 | 0.79 | SMN1; SMN2 (0.58) | KMT2ASMN1; SMN2RAB9AHTTKDM4E | |
| SCHEMBL22468550 | 0.79 | SMN1; SMN2 (0.58) | KMT2ASMN1; SMN2RAB9AHTTKDM4E | |
| SCHEMBL18420793 | 0.76 | SMN1; SMN2 (0.66) | KMT2ASMN1; SMN2RAB9AHTTKDM4E | |
| SCHEMBL14630700 | 0.74 | CA1 (0.53) | KMT2ASMN1; SMN2RAB9AHTTKDM4E | |
| SCHEMBL3890906 | 0.73 | SMN1; SMN2 (0.62) | KMT2ASMN1; SMN2RAB9AHTTKDM4E | |
| SCHEMBL5070509 | 0.73 | SMN1; SMN2 (0.58) | KMT2ASMN1; SMN2RAB9AHTTKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2024151547-A1 | TARGETED DEGRADATION OF VAV1 | MONTE ROSA THERAPEUTICS, INC. (US) | 2024-07-18 | — | — | WO | disclosed |