Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.58 |
| ▸ | PARP1 | P09874 | 2/20 | 0.57 |
| ▸ | MEN1 | O00255 | 1/20 | 0.55 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.55 |
| ▸ | CACNA1G | O43497 | 3/20 | 0.55 |
| ▸ | GLA | P06280 | 1/20 | 0.55 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.55 |
| ▸ | ERN1 | O75460 | 1/20 | 0.55 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.54 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.54 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.54 |
| ▸ | POLB | P06746 | 1/20 | 0.54 |
| ▸ | HPGD | P15428 | 1/20 | 0.54 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.54 |
| ▸ | MAPT | P10636 | 1/20 | 0.54 |
| ▸ | SMYD2 | Q9NRG4 | 1/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13675357 | 0.99 | PARP1 (0.58) | NPSR1PARP1MEN1KMT2ACACNA1G | |
| SCHEMBL13060642 | 0.93 | ERN1 (0.62) | NPSR1PARP1MEN1KMT2ACACNA1G | |
| SCHEMBL13061007 | 0.92 | ERN1 (0.64) | NPSR1PARP1MEN1KMT2ACACNA1G | |
| SCHEMBL5476524 | 0.91 | SMYD2 (0.62) | PARP1MEN1KMT2AL3MBTL1ALDH1A1 | |
| SCHEMBL10264071 | 0.89 | CYP2C19 (0.69) | PARP1KMT2AERN1CYP2C9ALDH1A1 | |
| Hydrochloric Acid SCHEMBL2457432 | 0.86 | ALDH1A1 (0.56) | NPSR1PARP1CACNA1GERN1CYP2C9 | |
| SCHEMBL19634715 | 0.86 | PARP1 (0.58) | NPSR1PARP1CACNA1GERN1CYP2C9 | |
| SCHEMBL13060850 | 0.85 | SMYD2 (0.67) | PARP1MEN1KMT2AL3MBTL1ERN1 | |
| SCHEMBL13060855 | 0.84 | CHRM3 (0.57) | PARP1ERN1CYP2C9CYP2C19MAPT | |
| SCHEMBL4268373 | 0.84 | MAPT (0.73) | NPSR1MEN1KMT2AGLAL3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8022222-B2 | Glucokinase activators | ARRAY BIOPHARMA, INC. (US) | 2011-09-20 | — | — | US | disclosed |
| US-20100099713-A1 | 2-AMINOPYRIDINE DERIVATIVES AS GLUCOKINASE ACTIVATORS | ARRAY BIOPHARMA INC. (US) | 2010-04-22 | — | — | US | disclosed |
| US-20090247526-A1 | GLUCOKINASE ACTIVATORS | ARRAY BIOPHARMA INC. (US) | 2009-10-01 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090247526-A1 | GLUCOKINASE ACTIVATORS | GCKR, GCK, GALK1 | NPSR1 4344/4885PARP1 3448/4885MEN1 3595/4885 |
| US-20100099713-A1 | 2-AMINOPYRIDINE DERIVATIVES AS GLUCOKINASE ACTIVATORS | GCKR, GCK, GALK1 | NPSR1 3988/4885PARP1 1707/4885MEN1 3658/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.