Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RORC | P51449 | 3/20 | 0.58 |
| ▸ | ITGB1 | P05556 | 2/20 | 0.54 |
| ▸ | ITGA4 | P13612 | 2/20 | 0.54 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.51 |
| ▸ | GAA | P10253 | 1/20 | 0.51 |
| ▸ | MAPT | P10636 | 1/20 | 0.51 |
| ▸ | RAB9A | P51151 | 1/20 | 0.51 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.51 |
| ▸ | IL2 | P60568 | 1/20 | 0.51 |
| ▸ | TLR7 | Q9NYK1 | 4/20 | 0.48 |
| ▸ | TYK2 | P29597 | 2/20 | 0.48 |
| ▸ | JAK2 | O60674 | 1/20 | 0.47 |
| ▸ | JAK1 | P23458 | 1/20 | 0.47 |
| ▸ | HTT | P42858 | 1/20 | 0.47 |
| ▸ | NOD2 | Q9HC29 | 1/20 | 0.47 |
| ▸ | TLR8 | Q9NR97 | 5/20 | 0.46 |
| ▸ | TRPA1 | O75762 | 3/20 | 0.45 |
| ▸ | MLYCD | O95822 | 1/20 | 0.45 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12334582 | 0.90 | RORC (0.61) | RORCSMN1; SMN2GAAMAPTRAB9A | |
| SCHEMBL12334258 | 0.84 | TLR8 (0.61) | RORCSMN1; SMN2GAAMAPTRAB9A | |
| SCHEMBL8657575 | 0.81 | SMN1; SMN2 (0.54) | RORCSMN1; SMN2GAAMAPTRAB9A | |
| SCHEMBL12334378 | 0.81 | RORC (0.72) | RORCITGB1ITGA4SMN1; SMN2GAA | |
| SCHEMBL14887755 | 0.80 | RAB9A (0.55) | ITGB1ITGA4GAAMAPTRAB9A | |
| SCHEMBL12334663 | 0.80 | RORC (0.71) | RORCSMN1; SMN2GAARAB9AMLYCD | |
| SCHEMBL12334586 | 0.78 | RORC (0.72) | RORCSMN1; SMN2MAPTRAB9AHTT | |
| SCHEMBL12334246 | 0.77 | RAB9A (0.61) | SMN1; SMN2GAAMAPTRAB9ANPSR1 | |
| SCHEMBL31078087 | 0.76 | RORC (0.65) | RORCSMN1; SMN2MAPTRAB9ANPSR1 | |
| SCHEMBL21652170 | 0.75 | HDAC3 (0.53) | RORCITGB1ITGA4GAAMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011115892-A1 | MODULATORS OF THE RETINOIC ACID RECEPTOR-RELATED ORPHAN RECEPTORS | GRIFFIN PATRICK R (US) | 2011-09-22 | — | — | WO | disclosed |