Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 9/20 | 0.54 |
| ▸ | RAB9A | P51151 | 7/20 | 0.54 |
| ▸ | HPGD | P15428 | 5/20 | 0.54 |
| ▸ | NPC1 | O15118 | 4/20 | 0.54 |
| ▸ | POLB | P06746 | 2/20 | 0.54 |
| ▸ | RIPK2 | O43353 | 1/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.47 |
| ▸ | MEN1 | O00255 | 2/20 | 0.47 |
| ▸ | MAPT | P10636 | 4/20 | 0.47 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.47 |
| ▸ | LMNA | P02545 | 3/20 | 0.47 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.47 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.47 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.46 |
| ▸ | GLA | P06280 | 1/20 | 0.45 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.45 |
| ▸ | S1PR4 | O95977 | 1/20 | 0.44 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.44 |
| ▸ | HTT | P42858 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1803890 | 0.87 | SMN1; SMN2 (0.54) | SMN1; SMN2RAB9AHPGDNPC1POLB | |
| SCHEMBL11700016 | 0.83 | LMNA (0.61) | SMN1; SMN2RAB9AHPGDNPC1POLB | |
| SCHEMBL14648634 | 0.83 | ALDH1A1 (0.63) | SMN1; SMN2RAB9AHPGDNPC1RIPK2 | |
| SCHEMBL13741601 | 0.81 | SMN1; SMN2 (0.49) | SMN1; SMN2RAB9AHPGDNPC1RIPK2 | |
| SCHEMBL23558009 | 0.81 | SMN1; SMN2 (0.65) | SMN1; SMN2RAB9AHPGDNPC1POLB | |
| SCHEMBL4055792 | 0.81 | LMNA (0.71) | SMN1; SMN2RAB9AHPGDNPC1POLB | |
| SCHEMBL4070024 | 0.81 | KMT2A (0.50) | SMN1; SMN2RAB9AHPGDNPC1KMT2A | |
| SCHEMBL2461662 | 0.79 | SMN1; SMN2 (0.66) | SMN1; SMN2RAB9AHPGDNPC1POLB | |
| SCHEMBL4701762 | 0.78 | ALDH1A1 (0.60) | SMN1; SMN2RAB9AHPGDRIPK2MAPT | |
| SCHEMBL1802850 | 0.76 | RIPK2 (0.52) | SMN1; SMN2RAB9AHPGDNPC1POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20130023534-A1 | PYRAZOLYL-PYRIMIDINES AS KINASE INHIBITORS | GLAXO GROUP LIMITED (GB) | 2013-01-24 | — | — | US | disclosed |
| WO-2011120026-A1 | PYRAZOLYL-PYRIMIDINES AS KINASE INHIBITORS | GLAXO GROUP LIMITED (GB) | 2011-09-29 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20130023534-A1 | PYRAZOLYL-PYRIMIDINES AS KINASE INHIBITORS | CDK2, MAP3K19, MAP3K1 | SMN1; SMN2 4325/4885RAB9A 1080/4885HPGD 2867/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.