Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNH2 | Q12809 | 1/20 | 0.44 |
| ▸ | EPHX1 | P07099 | 3/20 | 0.39 |
| ▸ | SSTR4 | P31391 | 8/20 | 0.39 |
| ▸ | SSTR1 | P30872 | 6/20 | 0.39 |
| ▸ | PDK1 | Q15118 | 1/20 | 0.38 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.38 |
| ▸ | PDK3 | Q15120 | 1/20 | 0.38 |
| ▸ | PDK4 | Q16654 | 1/20 | 0.38 |
| ▸ | GNAI3 | P08754 | 1/20 | 0.38 |
| ▸ | GNAO1 | P09471 | 1/20 | 0.38 |
| ▸ | GNAI1 | P63096 | 1/20 | 0.38 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.38 |
| ▸ | ACSS2 | Q9NR19 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | KDM1A | O60341 | 1/20 | 0.36 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.35 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.35 |
| ▸ | PKM | P14618 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12334950 | 0.83 | KCNH2 (0.47) | KCNH2EPHX1SSTR4SSTR1PDK1 | |
| SCHEMBL12308685 | 0.83 | KCNH2 (0.38) | KCNH2EPHX1SSTR4SSTR1PDK1 | |
| SCHEMBL3402629 | 0.81 | EPHX1 (0.45) | KCNH2EPHX1SSTR4SSTR1PDK1 | |
| SCHEMBL3405244 | 0.81 | EPHX1 (0.45) | KCNH2EPHX1SSTR4SSTR1PDK1 | |
| SCHEMBL1029383 | 0.81 | EPHX1 (0.45) | KCNH2EPHX1SSTR4SSTR1PDK1 | |
| Hydrochloric Acid SCHEMBL1878764 | 0.80 | EPHX1 (0.44) | KCNH2EPHX1SSTR4SSTR1PDK1 | |
| Hydrochloric Acid SCHEMBL1027224 | 0.80 | EPHX1 (0.44) | KCNH2EPHX1SSTR4SSTR1PDK1 | |
| Hydrochloric Acid SCHEMBL1873541 | 0.80 | EPHX1 (0.44) | KCNH2EPHX1SSTR4SSTR1PDK1 | |
| SCHEMBL382773 | 0.78 | EPHX1 (0.45) | KCNH2EPHX1SSTR4SSTR1PDK1 | |
| SCHEMBL5873642 | 0.78 | EPHX1 (0.45) | KCNH2EPHX1SSTR4SSTR1PDK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8017638-B2 | Isoxazole derivative and isothiazole derivative having inhibitory activity on 11β-hydroxysteroid dehydrogenase type 1 | SHIONOGI & CO., LTD. (JP) | 2011-09-13 | — | — | US | disclosed |
| US-20090131491-A1 | ISOXAZOLE DERIVATIVE AND ISOTHIAZOLE DERIVATIVE HAVING INHIBITORY ACTIVITY ON 11(beta)-HYDROXYSTEROID DEHYDROGENASE TYPE I | SHIONOGI & CO., LTD. (JP) | 2009-05-21 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090131491-A1 | ISOXAZOLE DERIVATIVE AND ISOTHIAZOLE DERIVATIVE HAVING INHIBITORY ACTIVITY ON 11(beta)-HYDROXYSTEROID DEHYDROGENASE TYPE I | HSD3B1, NR5A1, HSD11B1 | KCNH2 1745/4885EPHX1 1338/4885SSTR4 2250/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.