Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | P4HTM | Q9NXG6 | 1/20 | 0.55 |
| ▸ | KCNQ3 | O43525 | 2/20 | 0.54 |
| ▸ | KCNQ2 | O43526 | 2/20 | 0.54 |
| ▸ | MEN1 | O00255 | 2/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.53 |
| ▸ | F10 | P00742 | 1/20 | 0.52 |
| ▸ | HDAC1 | Q13547 | 4/20 | 0.52 |
| ▸ | HDAC3 | O15379 | 3/20 | 0.52 |
| ▸ | HDAC2 | Q92769 | 3/20 | 0.52 |
| ▸ | HDAC4 | P56524 | 2/20 | 0.52 |
| ▸ | HDAC7 | Q8WUI4 | 2/20 | 0.52 |
| ▸ | HDAC10 | Q969S8 | 2/20 | 0.52 |
| ▸ | HDAC11 | Q96DB2 | 2/20 | 0.52 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.52 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.52 |
| ▸ | HDAC9 | Q9UKV0 | 2/20 | 0.52 |
| ▸ | HDAC5 | Q9UQL6 | 2/20 | 0.52 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.52 |
| ▸ | RAB9A | P51151 | 4/20 | 0.52 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2303029 | 0.86 | KMT2A (0.59) | P4HTMKCNQ3KCNQ2MEN1KMT2A | |
| SCHEMBL4061498 | 0.86 | P4HTM (0.72) | P4HTMKCNQ3KCNQ2MEN1KMT2A | |
| SCHEMBL3199765 | 0.86 | P4HTM (0.56) | P4HTMKCNQ3KCNQ2MEN1KMT2A | |
| SCHEMBL1235341 | 0.84 | RAB9A (0.63) | KCNQ3KCNQ2MEN1KMT2AHDAC1 | |
| SCHEMBL1235368 | 0.83 | HDAC1 (0.60) | KCNQ3KCNQ2MEN1KMT2AF10 | |
| SCHEMBL6705958 | 0.81 | MAPT (0.68) | MEN1KMT2ASMN1; SMN2RAB9AMAPK1 | |
| SCHEMBL1233691 | 0.81 | HDAC1 (0.68) | KCNQ3KCNQ2HDAC1HDAC3HDAC2 | |
| SCHEMBL1235248 | 0.81 | HDAC1 (0.66) | P4HTMF10HDAC1HDAC3HDAC2 | |
| SCHEMBL2302302 | 0.79 | RAB9A (0.72) | P4HTMKCNQ3KCNQ2MEN1KMT2A | |
| SCHEMBL27835137 | 0.79 | HDAC1 (0.52) | MEN1KMT2AF10HDAC1HDAC3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-102020638-B | 2-indolinone derivative with protein kinase inhibition activity and histone deacetylase inhibition activity and preparation method and application thereof | SHENZHEN CHIPSCREEN BIOSCIENCES LTD | 2013-05-08 | — | — | CN | disclosed |
| CN-102020607-B | 6-aminoniacinamide derivatives with histone deacetylase inhibiting activity, preparation method and application thereof | SHENZHEN CHIPSCREEN BIOSCIENCES LTD | 2013-01-23 | — | — | CN | disclosed |
| US-8158656-B2 | 2-indolinone derivatives as multi-target protein kinase inhibitors and histone deacetylase inhibitors | SHENZHEN CHIPSCREEN BIOSCIENCES LTD. (CN) | 2012-04-17 | — | — | US | disclosed |
| US-8158656-B2 | 2-indolinone derivatives as multi-target protein kinase inhibitors and histone deacetylase inhibitors | SHENZHEN CHIPSCREEN BIOSCIENCES LTD. (CN) | 2012-04-17 | — | — | US | disclosed |
| US-8158656-B2 | 2-indolinone derivatives as multi-target protein kinase inhibitors and histone deacetylase inhibitors | SHENZHEN CHIPSCREEN BIOSCIENCES LTD. (CN) | 2012-04-17 | — | — | US | disclosed |
| EP-2285376-A1 | 6-AMINONICOTINAMIDE DERIVATIVES AS POTENT AND SELECTIVE HISTONE DEACETYLASE INHIBITORS | Chipscreen Biosciences Ltd. (CN) | 2011-02-23 | — | — | EP | disclosed |
| US-20090298886-A1 | 2-INDOLINONE DERIVATIVES AS MULTI-TARGET PROTEIN KINASE INHIBITORS AND HISTONE DEACETYLASE INHIBITORS | CHIPSCREEN BIOSCIENCES, LTD. (CN) | 2009-12-03 | — | — | US | disclosed |
| US-20090298886-A1 | 2-INDOLINONE DERIVATIVES AS MULTI-TARGET PROTEIN KINASE INHIBITORS AND HISTONE DEACETYLASE INHIBITORS | CHIPSCREEN BIOSCIENCES, LTD. (CN) | 2009-12-03 | — | — | US | disclosed |
| US-20090298886-A1 | 2-INDOLINONE DERIVATIVES AS MULTI-TARGET PROTEIN KINASE INHIBITORS AND HISTONE DEACETYLASE INHIBITORS | CHIPSCREEN BIOSCIENCES, LTD. (CN) | 2009-12-03 | — | — | US | disclosed |
| WO-2009140164-A1 | 6-AMINONICOTINAMIDE DERIVATIVES AS POTENT AND SELECTIVE HISTONE DEACETYLASE INHIBITORS | CHIPSCREEN BIOSCIENCES LTD. (CN) | 2009-11-19 | — | — | WO | disclosed |
| WO-2009140164-A1 | 6-AMINONICOTINAMIDE DERIVATIVES AS POTENT AND SELECTIVE HISTONE DEACETYLASE INHIBITORS | CHIPSCREEN BIOSCIENCES LTD. (CN) | 2009-11-19 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090298886-A1 | 2-INDOLINONE DERIVATIVES AS MULTI-TARGET PROTEIN KINASE INHIBITORS AND HISTONE DEACETYLASE INHIBITORS | HDAC1, HDAC2, HDAC3 | P4HTM 3295/4885KCNQ3 3519/4885KCNQ2 2939/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.