Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAB9A | P51151 | 3/20 | 0.63 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.63 |
| ▸ | MDM4 | O15151 | 1/20 | 0.53 |
| ▸ | TP53 | P04637 | 1/20 | 0.53 |
| ▸ | MDM2 | Q00987 | 1/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.52 |
| ▸ | MEN1 | O00255 | 4/20 | 0.52 |
| ▸ | NPC1 | O15118 | 2/20 | 0.52 |
| ▸ | POLB | P06746 | 1/20 | 0.52 |
| ▸ | HDAC1 | Q13547 | 5/20 | 0.51 |
| ▸ | HDAC3 | O15379 | 4/20 | 0.51 |
| ▸ | HDAC4 | P56524 | 4/20 | 0.51 |
| ▸ | HDAC7 | Q8WUI4 | 4/20 | 0.51 |
| ▸ | HDAC2 | Q92769 | 4/20 | 0.51 |
| ▸ | HDAC10 | Q969S8 | 4/20 | 0.51 |
| ▸ | HDAC11 | Q96DB2 | 4/20 | 0.51 |
| ▸ | HDAC8 | Q9BY41 | 4/20 | 0.51 |
| ▸ | HDAC6 | Q9UBN7 | 4/20 | 0.51 |
| ▸ | HDAC9 | Q9UKV0 | 4/20 | 0.51 |
| ▸ | HDAC5 | Q9UQL6 | 4/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1235368 | 0.86 | HDAC1 (0.60) | RAB9ASMN1; SMN2MDM4TP53MDM2 | |
| SCHEMBL1233691 | 0.84 | HDAC1 (0.68) | RAB9AMDM4TP53MDM2NPC1 | |
| SCHEMBL1233658 | 0.84 | P4HTM (0.55) | RAB9ASMN1; SMN2MDM4TP53MDM2 | |
| SCHEMBL27835137 | 0.82 | HDAC1 (0.52) | RAB9ASMN1; SMN2MDM4TP53MDM2 | |
| SCHEMBL16886015 | 0.81 | NPC1 (0.61) | RAB9ASMN1; SMN2KMT2AMEN1NPC1 | |
| SCHEMBL1233684 | 0.81 | KCNQ3 (0.60) | RAB9ASMN1; SMN2MDM4TP53MDM2 | |
| SCHEMBL6709850 | 0.81 | RAB9A (0.59) | RAB9ASMN1; SMN2MDM4TP53MDM2 | |
| SCHEMBL1064912 | 0.81 | MDM4 (0.70) | RAB9ASMN1; SMN2MDM4TP53MDM2 | |
| SCHEMBL6707243 | 0.80 | GAA (0.61) | RAB9ASMN1; SMN2MDM4TP53MDM2 | |
| SCHEMBL1235343 | 0.79 | HDAC1 (0.53) | SMN1; SMN2KMT2AMEN1POLBHDAC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8158656-B2 | 2-indolinone derivatives as multi-target protein kinase inhibitors and histone deacetylase inhibitors | SHENZHEN CHIPSCREEN BIOSCIENCES LTD. (CN) | 2012-04-17 | — | — | US | disclosed |
| US-8158656-B2 | 2-indolinone derivatives as multi-target protein kinase inhibitors and histone deacetylase inhibitors | SHENZHEN CHIPSCREEN BIOSCIENCES LTD. (CN) | 2012-04-17 | — | — | US | disclosed |
| US-8158656-B2 | 2-indolinone derivatives as multi-target protein kinase inhibitors and histone deacetylase inhibitors | SHENZHEN CHIPSCREEN BIOSCIENCES LTD. (CN) | 2012-04-17 | — | — | US | disclosed |
| EP-2285376-A1 | 6-AMINONICOTINAMIDE DERIVATIVES AS POTENT AND SELECTIVE HISTONE DEACETYLASE INHIBITORS | Chipscreen Biosciences Ltd. (CN) | 2011-02-23 | — | — | EP | disclosed |
| US-20090298886-A1 | 2-INDOLINONE DERIVATIVES AS MULTI-TARGET PROTEIN KINASE INHIBITORS AND HISTONE DEACETYLASE INHIBITORS | CHIPSCREEN BIOSCIENCES, LTD. (CN) | 2009-12-03 | — | — | US | disclosed |
| US-20090298886-A1 | 2-INDOLINONE DERIVATIVES AS MULTI-TARGET PROTEIN KINASE INHIBITORS AND HISTONE DEACETYLASE INHIBITORS | CHIPSCREEN BIOSCIENCES, LTD. (CN) | 2009-12-03 | — | — | US | disclosed |
| US-20090298886-A1 | 2-INDOLINONE DERIVATIVES AS MULTI-TARGET PROTEIN KINASE INHIBITORS AND HISTONE DEACETYLASE INHIBITORS | CHIPSCREEN BIOSCIENCES, LTD. (CN) | 2009-12-03 | — | — | US | disclosed |
| WO-2009140164-A1 | 6-AMINONICOTINAMIDE DERIVATIVES AS POTENT AND SELECTIVE HISTONE DEACETYLASE INHIBITORS | CHIPSCREEN BIOSCIENCES LTD. (CN) | 2009-11-19 | — | — | WO | disclosed |
| WO-2009140164-A1 | 6-AMINONICOTINAMIDE DERIVATIVES AS POTENT AND SELECTIVE HISTONE DEACETYLASE INHIBITORS | CHIPSCREEN BIOSCIENCES LTD. (CN) | 2009-11-19 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090298886-A1 | 2-INDOLINONE DERIVATIVES AS MULTI-TARGET PROTEIN KINASE INHIBITORS AND HISTONE DEACETYLASE INHIBITORS | HDAC1, HDAC2, HDAC3 | RAB9A 1800/4885SMN1; SMN2 3901/4885MDM4 3676/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.